Robin J Mockett
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Explore the profile of Robin J Mockett including associated specialties, affiliations and a list of published articles.
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21
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712
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Recent Articles
1.
Bearden A, Stewart E, Casher C, Shaddix M, Nobles A, Mockett R
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519056
Various dietary supplements have been shown to extend the life span of , including several that promote autophagy, such as rapamycin and spermidine. The goal of the study presented here...
2.
Herbal supplement extends life span under some environmental conditions and boosts stress resistance
Villeponteau B, Matsagas K, Nobles A, Rizza C, Horwitz M, Benford G, et al.
PLoS One
. 2015 Apr;
10(4):e0119068.
PMID: 25879540
Genetic studies indicate that aging is modulated by a great number of genetic pathways. We have used Drosophila longevity and stress assays to test a multipath intervention strategy. To carry...
3.
Mockett R, Matsumoto Y
PLoS One
. 2014 Mar;
9(3):e92228.
PMID: 24632815
The laboratory fruit fly, Drosophila melanogaster, is used widely in biological research, but the requirement to maintain stocks with a roughly biweekly generation time imposes substantial burdens of labor, potential...
4.
Mockett R, Nobles A
J Gerontol A Biol Sci Med Sci
. 2013 Jun;
68(10):1157-69.
PMID: 23729660
The hypothesis tested in this study was that single-gene mutations found previously to extend the life span of Drosophila melanogaster could do so consistently in both long-lived y w and...
5.
Mockett R, Cockrell J, Puri S, Nguyen M, Nisa M
Mech Ageing Dev
. 2012 Apr;
133(5):359-67.
PMID: 22525703
Numerous single-gene mutations obtained by insertion of P elements in white (w) genetic backgrounds have been reported to extend the life span of Drosophila melanogaster, but life extension is sometimes...
6.
Mockett R, Sohal B, Sohal R
Free Radic Biol Med
. 2010 Oct;
49(12):2028-31.
PMID: 20923705
The simultaneous overexpression of multiple copies of Mn superoxide dismutase (SOD) and ectopic catalase (mtCat) transgenes in the mitochondria of the fruit fly, Drosophila melanogaster, was shown previously to diminish...
7.
Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster
Legan S, Rebrin I, Mockett R, Radyuk S, Klichko V, Sohal R, et al.
J Biol Chem
. 2008 Sep;
283(47):32492-9.
PMID: 18809674
The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement of reductive capacity by overexpression of...
8.
Sohal R, Toroser D, Bregere C, Mockett R, Orr W
Mech Ageing Dev
. 2008 Jun;
129(9):558-61.
PMID: 18538373
A key feature of the aging process is that the mitochondrial respiratory capacity declines and, the production of reactive oxygen species increases in the later part of life span. In...
9.
Mockett R, Sohal R
Exp Gerontol
. 2006 May;
41(6):566-73.
PMID: 16677788
Single gene, hypomorphic mutations which extend the life spans of cold-blooded animals, such as the methuselah (mth) mutation in the fruit fly, Drosophila melanogaster, may have additional, deleterious effects on...
10.
Mockett R, Cooper T, Orr W, Sohal R
Biogerontology
. 2006 Apr;
7(3):157-60.
PMID: 16628489
This article addresses two questions: (1) 'can caloric restriction (CR) extend the life spans of all species of experimental animals', and (2) 'is CR likely to slow the human aging...