Robin J G Hartman
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Explore the profile of Robin J G Hartman including associated specialties, affiliations and a list of published articles.
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13
Citations
165
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Recent Articles
1.
Yang Y, Dashi A, Soong P, Lin K, Tan W, Pan B, et al.
J Mol Cell Cardiol
. 2024 Nov;
197:90-102.
PMID: 39490643
Rationale: Cardiac-expressed long noncoding RNAs (lncRNAs) are important for cardiomyocyte (CM) differentiation and function. Several lncRNAs have been identified and characterized for early CM lineage commitment, however those in later...
2.
Diez Benavente E, Hartman R, Sakkers T, Wesseling M, Sloots Y, Slenders L, et al.
Arterioscler Thromb Vasc Biol
. 2024 Apr;
44(6):1419-1431.
PMID: 38634280
Background: Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques is predictive for the risk of...
3.
Mokry M, Boltjes A, Slenders L, Bel-Bordes G, Cui K, Brouwer E, et al.
Nat Cardiovasc Res
. 2023 Nov;
1(12):1140-1155.
PMID: 37920851
Histopathological studies have revealed key processes of atherosclerotic plaque thrombosis. However, the diversity and complexity of lesion types highlight the need for improved sub-phenotyping. Here we analyze the gene expression...
4.
Diez Benavente E, Karnewar S, Buono M, Mili E, Hartman R, Kapteijn D, et al.
Arterioscler Thromb Vasc Biol
. 2023 Aug;
43(10):1836-1850.
PMID: 37589136
Background: Women presenting with coronary artery disease more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How...
5.
Diez Benavente E, Karnewar S, Buono M, Mili E, Hartman R, Kapteijn D, et al.
bioRxiv
. 2023 Feb;
PMID: 36798294
Women presenting with coronary artery disease (CAD) more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How...
6.
Buono M, Slenders L, Wesseling M, Hartman R, Monaco C, den Ruijter H, et al.
Vascul Pharmacol
. 2021 Oct;
141:106924.
PMID: 34607015
For decades, the pathological definition of the vulnerable plaque led to invaluable insights into the mechanisms that underlie myocardial infarction and stroke. Beyond plaque rupture, other mechanisms, such as erosion,...
7.
Hartman R, Mokry M, Pasterkamp G, den Ruijter H
Sci Rep
. 2021 Sep;
11(1):18758.
PMID: 34548535
Many pathophysiological mechanisms in human health and disease are dependent on sex. Systems biology approaches are successfully used to decipher human disease etiology, yet the effect of sex on gene...
8.
Groepenhoff F, Diez Benavente E, Boltjes A, Timmerman N, Waissi F, Hartman R, et al.
Front Cardiovasc Med
. 2021 Jul;
8:693351.
PMID: 34195238
Low plasma testosterone levels have been shown to predict worse outcome in men with severe atherosclerotic disease. We hypothesized that a low plasma testosterone level affects disease risk through changes...
9.
Hartman R, Owsiany K, Ma L, Koplev S, Hao K, Slenders L, et al.
Circulation
. 2021 Jan;
143(7):713-726.
PMID: 33499648
Background: Although sex differences in coronary artery disease are widely accepted with women developing more stable atherosclerosis than men, the underlying pathobiology of such differences remains largely unknown. In coronary...
10.
Hartman R, Kapteijn D, Haitjema S, Bekker M, Mokry M, Pasterkamp G, et al.
Sci Rep
. 2020 Jul;
10(1):12367.
PMID: 32704153
Sex differences in endothelial cell (EC) biology may reflect intrinsic differences driven by chromosomes or sex steroid exposure and gender differences accumulated over life. We analysed EC gene expression data...