Robin Ernst
Overview
Explore the profile of Robin Ernst including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
264
Followers
0
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Recent Articles
1.
Van Kolen K, Malia T, Theunis C, Nanjunda R, Teplyakov A, Ernst R, et al.
J Alzheimers Dis
. 2020 Sep;
77(4):1397-1416.
PMID: 32894244
Background: As a consequence of the discovery of an extracellular component responsible for the progression of tau pathology, tau immunotherapy is being extensively explored in both preclinical and clinical studies...
2.
Venkataramani S, Ernst R, Derebe M, Wright R, Kopenhaver J, Jacobs S, et al.
Sci Rep
. 2020 Jun;
10(1):9722.
PMID: 32546687
Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeutics using transgenic animals with a notion that such mAbs bypass humanization. A transgenic animal derived mAb (PCa75) targeted against...
3.
Tam S, McCarthy S, Armstrong A, Somani S, Wu S, Liu X, et al.
Antibodies (Basel)
. 2019 Sep;
6(3).
PMID: 31548527
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc...
4.
Malia T, Teplyakov A, Ernst R, Wu S, Lacy E, Liu X, et al.
Proteins
. 2016 Jan;
84(4):427-34.
PMID: 26800003
Microtubule-associated protein tau becomes abnormally phosphorylated in Alzheimer's disease and other tauopathies and forms aggregates of paired helical filaments (PHF-tau). AT8 is a PHF-tau-specific monoclonal antibody that is a commonly...
5.
Chiu C, Peekhaus N, Weber H, Adamski S, Murray E, Zhang H, et al.
J Gerontol A Biol Sci Med Sci
. 2013 Mar;
68(10):1181-92.
PMID: 23525481
Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A fusion protein consisting of the extracellular...
6.
Zhang L, McCabe T, Condra J, Ni Y, Peterson L, Wang W, et al.
Int J Biol Sci
. 2012 Feb;
8(3):310-27.
PMID: 22355267
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and...
7.
Ebert T, Smith S, Pancari G, Clark D, Hampton R, Secore S, et al.
Hum Antibodies
. 2010 Dec;
19(4):113-28.
PMID: 21178283
A fully human monoclonal antibody (CS-D7, IgG1) specific for the iron regulated surface determinant B (IsdB) of Staphylococcus aureus was isolated from the Cambridge Antibody Technology (CAT) scFv antibody library....
8.
Glantschnig H, Hampton R, Lu P, Zhao J, Vitelli S, Huang L, et al.
J Biol Chem
. 2010 Oct;
285(51):40135-47.
PMID: 20929859
Wnt/LRP5 signaling is a central regulatory component of bone formative and resorptive activities, and the pathway inhibitor DKK1 is a suppressor of bone formation and bone mass accrual in mice....