Robin D Hatton
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Explore the profile of Robin D Hatton including associated specialties, affiliations and a list of published articles.
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31
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7064
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Recent Articles
1.
Zindl C, Wilson C, Chadha A, Duck L, Cai B, Harbour S, et al.
Nature
. 2024 Apr;
629(8012):669-678.
PMID: 38600382
Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier. T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling...
2.
Dean E, Ditoro D, Pham D, Gao M, Zindl C, Frey B, et al.
bioRxiv
. 2023 Oct;
PMID: 37808649
Maintenance of immune homeostasis to the intestinal mictrobiota is dependent on a population of effector regulatory T (eTreg) cells that develop from microbiota-reactive induced (i)Treg cells. A cardinal feature of...
3.
Pham D, Silberger D, Nguyen K, Gao M, Weaver C, Hatton R
EMBO J
. 2023 Mar;
42(8):e109803.
PMID: 36917143
Although the activator protein-1 (AP-1) factor Batf is required for Th17 cell development, its mechanisms of action to underpin the Th17 program are incompletely understood. Here, we find that Batf...
4.
Zindl C, Witte S, Laufer V, Gao M, Yue Z, Janowski K, et al.
Immunity
. 2022 Mar;
55(3):494-511.e11.
PMID: 35263568
Interleukin (IL)-22 is central to immune defense at barrier sites. We examined the contributions of innate lymphoid cell (ILC) and T cell-derived IL-22 during Citrobacter rodentium (C.r) infection using mice...
5.
Harbour S, Ditoro D, Witte S, Zindl C, Gao M, Schoeb T, et al.
Sci Immunol
. 2020 Jul;
5(49).
PMID: 32680955
Acting in concert with TGF-β, interleukin-6 (IL-6) signaling induces T helper 17 (T17) cell development by programming T17-related genes via signal transducers and activators of transcription 3 (STAT3). A role...
6.
DiToro D, Harbour S, Bando J, Benavides G, Witte S, Laufer V, et al.
Immunity
. 2020 Apr;
52(4):650-667.e10.
PMID: 32294406
Appropriate balance of T helper 17 (Th17) and regulatory T (Treg) cells maintains immune tolerance and host defense. Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated...
7.
Pham D, Moseley C, Gao M, Savic D, Winstead C, Sun M, et al.
Cell Rep
. 2019 Oct;
29(5):1203-1220.e7.
PMID: 31665634
The basic leucine zipper transcription factor activating transcription factor-like (Batf) contributes to transcriptional programming of multiple effector T cells and is required for T helper 17 (Th17) and T follicular...
8.
DiToro D, Winstead C, Pham D, Witte S, Andargachew R, Singer J, et al.
Science
. 2018 Sep;
361(6407).
PMID: 30213884
In response to infection, naïve CD4 T cells differentiate into two subpopulations: T follicular helper (T) cells, which support B cell antibody production, and non-T cells, which enhance innate immune...
9.
Whitley S, Balasubramani A, Zindl C, Sen R, Shibata Y, Crawford G, et al.
J Biol Chem
. 2018 Aug;
293(41):15790-15800.
PMID: 30093408
Interleukin (IL)-1β plays a critical role in IL-6β- and transforming growth factor β (TGFβ)-initiated Th17 differentiation and induction of Th17-mediated autoimmunity. However, the means by which IL-1 regulates various aspects...
10.
Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, et al.
Nat Immunol
. 2015 Feb;
16(3):286-95.
PMID: 25642823
Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and CD4(+) inducible regulatory T cells (iTreg cells) emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic...