Roberto Takashi Sudo
Overview
Explore the profile of Roberto Takashi Sudo including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
162
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Recent Articles
1.
Silva G, Silva J, Nogueira de Alencar A, Silva M, Montagnoli T, de Souza Rocha B, et al.
Pharmaceuticals (Basel)
. 2022 Jul;
15(7).
PMID: 35890198
Mitogen-activated protein kinase (MAPK) signaling is strongly implicated in cardiovascular remodeling in pulmonary hypertension (PH) and right ventricle (RV) failure. The effects of a newly designed p38 inhibitor, LASSBio-1824, were...
2.
Vieira M, Monte F, Dematte B, Montagnoli T, Montes G, Silva J, et al.
J Pain Res
. 2021 Apr;
14:857-866.
PMID: 33833563
Introduction: New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli by neuron hyperpolarization via nitric oxide (NO)/cyclic 3',5'-guanosine...
3.
Silva M, Nogueira de Alencar A, Silva J, Montagnoli T, Silva G, de Souza Rocha B, et al.
Cells
. 2020 Sep;
9(9).
PMID: 32961896
Pulmonary arterial hypertension (PAH) is characterized by the remodeling of pulmonary arteries, with an increased pulmonary arterial pressure and right ventricle (RV) overload. This work investigated the benefit of the...
4.
Costa G, Montagnoli T, Silva J, Nogueira de Alencar A, Gamba L, Alves B, et al.
Drug Des Devel Ther
. 2020 Sep;
14:3337-3350.
PMID: 32884238
Introduction: Diabetic obese patients are susceptible to the development of cardiovascular disease, including hypertension and cardiac dysfunction culminating in diabetic cardiomyopathy (DC), which represents a life-threatening health problem with increased...
5.
Sudo R, do Amaral R, Monteiro C, da Rocha Pitta I, Lima M, Montes G, et al.
Eur J Pharmacol
. 2017 Sep;
815:210-218.
PMID: 28935564
The mechanisms and antinociceptive effects of a novel α adrenoceptor agonist, 3-(2-chloro-6-fluorobenzil)-imidazolinide-2,4-dione (PT-31) were investigated using animal models of acute and chronic pain. The effects of PT-31 on pain responses...
6.
Montes G, da Silva B, Rezende B, Sudo R, Ferreira V, de Carvalho da Silva F, et al.
Molecules
. 2017 May;
22(5).
PMID: 28509855
5'-4-Alkyl/aryl-1-1,2,3-triazole derivatives - were synthesized and a pharmacological screening of these derivatives was performed to identify a possible effect on the Central Nervous System (CNS) and to explore the associated...
7.
Zapata-Sudo G, da Costa Nunes I, Araujo J, Silva J, Trachez M, da Silva T, et al.
Drug Des Devel Ther
. 2016 Sep;
10:2869-2879.
PMID: 27672310
Neuropathy is a serious complication of diabetes that has a significant socioeconomic impact, since it frequently demands high levels of health care consumption and compromises labor productivity. Recently, LASSBio-1471 (3)...
8.
Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation
Montes G, Hammes N, da Rocha M, Montagnoli T, Fraga C, Barreiro E, et al.
J Pharmacol Exp Ther
. 2016 May;
358(2):315-23.
PMID: 27194479
Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays an important role in its pathophysiology. In vitro, (E)-N'-(3,4-dimethoxybenzylidene)-N-methylbenzohydrazide (LASSBio-1359) has exhibited anti-TNF-α properties, and in vivo...
9.
Moura V, Alencar A, Calasans-Maia J, Silva J, Fraga C, Zapata-Sudo G, et al.
Urology
. 2015 Apr;
85(5):1214.e17-1214.e21.
PMID: 25917739
Objective: To test the relaxation effect of a new adenosine receptor agonist N-acylhydrazone derivative, 3,4-dimethoxyphenyl-N-methyl-benzoylhydrazide (LASSBio-1359), on in vitro and in vivo preparation of corpus cavernosum (CC), and its interaction...
10.
da Silva T, Bispo Junior W, Alexandre-Moreira M, Costa F, Monteiro C, Ferreira F, et al.
Molecules
. 2015 Feb;
20(2):3067-88.
PMID: 25685912
The N-acylhydrazone (NAH) moiety is considered a privileged structure, being present in many compounds with diverse pharmacological activities. Among the activities attributed to NAH derivatives anti-inflammatory and analgesic ones are...