Roberto Contestabile
Overview
Explore the profile of Roberto Contestabile including associated specialties, affiliations and a list of published articles.
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Articles
81
Citations
1033
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Recent Articles
1.
Graziani C, Barile A, Parroni A, di Salvo M, De Cecio I, Colombo T, et al.
Protein Sci
. 2024 Nov;
33(12):e5242.
PMID: 39604152
The pyridoxal 5'-phosphate binding protein (PLP-BP) is believed to play a crucial role in PLP homeostasis, which may explain why it is found in living organisms from all kingdoms. Escherichia...
2.
Graziani C, Barile A, Antonelli L, Fiorillo A, Ilari A, Vetica F, et al.
FEBS J
. 2024 Sep;
291(22):4984-5001.
PMID: 39288205
Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B, acts as a cofactor in many metabolic processes. In humans, PLP is produced in the reactions catalysed by pyridox(am)ine 5'-phosphate...
3.
Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, et al.
Mol Cell
. 2024 Jul;
84(14):2682-2697.e6.
PMID: 38996576
RNA can directly control protein activity in a process called riboregulation; only a few mechanisms of riboregulation have been described in detail, none of which have been characterized on structural...
4.
Pilesi E, Tesoriere G, Ferriero A, Mascolo E, Liguori F, Argiro L, et al.
Cell Death Dis
. 2024 Jun;
15(6):388.
PMID: 38830901
Vitamin B6 is a water-soluble vitamin which possesses antioxidant properties. Its catalytically active form, pyridoxal 5'-phosphate (PLP), is a crucial cofactor for DNA and amino acid metabolism. The inverse correlation...
5.
Malatesta M, Fornasier E, di Salvo M, Tramonti A, Zangelmi E, Peracchi A, et al.
Nat Commun
. 2024 Apr;
15(1):3199.
PMID: 38615009
The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing...
6.
Barile A, Graziani C, Antonelli L, Parroni A, Fiorillo A, di Salvo M, et al.
Protein Sci
. 2024 Jan;
33(2):e4900.
PMID: 38284493
Adequate levels of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B , and its proper distribution in the body are essential for human health. The PLP recycling pathway...
7.
Tramonti A, Donkor A, Parroni A, Musayev F, Barile A, Ghatge M, et al.
FEBS J
. 2023 Sep;
290(23):5628-5651.
PMID: 37734924
Pyridoxine 4-dehydrogenase (PdxI), a NADPH-dependent pyridoxal reductase, is one of the key players in the Escherichia coli pyridoxal 5'-phosphate (PLP) salvage pathway. This enzyme, which catalyses the reduction of pyridoxal...
8.
Freda I, Exertier C, Barile A, Chaves-Sanjuan A, Vega M, Isupov M, et al.
Nucleic Acids Res
. 2023 Jun;
51(15):8237-8254.
PMID: 37378428
Specificity in protein-DNA recognition arises from the synergy of several factors that stem from the structural and chemical signatures encoded within the targeted DNA molecule. Here, we deciphered the nature...
9.
Pilesi E, Angioli C, Graziani C, Parroni A, Contestabile R, Tramonti A, et al.
J Cell Physiol
. 2023 May;
238(7):1558-1566.
PMID: 37183313
Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, participates as a cofactor to one carbon (1C) pathway that produces precursors for DNA metabolism. The concerted action of PLP-dependent...
10.
Babor J, Tramonti A, Nardella C, Deutschbauer A, Contestabile R, de Crecy-Lagard V
Microbiology (Reading)
. 2023 Apr;
169(4).
PMID: 37040165
Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B and a cofactor for many essential metabolic processes such as amino acid biosynthesis and one carbon metabolism. 4'-deoxypyridoxine (4dPN) is...