Roberto Battistutta
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Explore the profile of Roberto Battistutta including associated specialties, affiliations and a list of published articles.
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54
Citations
926
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Recent Articles
1.
Fornasier E, Fabbian S, Shehi H, Enderle J, Gatto B, Volpin D, et al.
Commun Biol
. 2024 Nov;
7(1):1435.
PMID: 39496839
Many enzymes work as homodimers with two distant catalytic sites, but the reason for this choice is often not clear. For the main protease M of SARS-CoV-2, dimerization is essential...
2.
Malatesta M, Fornasier E, di Salvo M, Tramonti A, Zangelmi E, Peracchi A, et al.
Nat Commun
. 2024 Apr;
15(1):3199.
PMID: 38615009
The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing...
3.
Fabbian S, Giachin G, Bellanda M, Borgo C, Ruzzene M, Spuri G, et al.
Front Mol Biosci
. 2022 Jun;
9:906390.
PMID: 35720133
CK2 is a Ser/Thr protein kinase involved in many cellular processes such as gene expression, cell cycle progression, cell growth and differentiation, embryogenesis, and apoptosis. Aberrantly high CK2 activity is...
4.
El Khoury L, Jing Z, Cuzzolin A, Deplano A, Loco D, Sattarov B, et al.
Chem Sci
. 2022 Apr;
13(13):3674-3687.
PMID: 35432906
We report a fast-track computationally driven discovery of new SARS-CoV-2 main protease (M) inhibitors whose potency ranges from mM for the initial non-covalent ligands to sub-μM for the final covalent...
5.
Fornasier E, Macchia M, Giachin G, Sosic A, Pavan M, Sturlese M, et al.
Acta Crystallogr D Struct Biol
. 2022 Mar;
78(Pt 3):363-378.
PMID: 35234150
The SARS-CoV-2 main protease (M) has a pivotal role in mediating viral genome replication and transcription of the coronavirus, making it a promising target for drugs against the COVID-19 pandemic....
6.
Abrusci G, Tarenzi T, Sturlese M, Giachin G, Battistutta R, Lattanzi G
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34361083
The mammalian protein prestin is expressed in the lateral membrane wall of the cochlear hair outer cells and is responsible for the electromotile response of the basolateral membrane, following hyperpolarisation...
7.
Costanzi E, Coletti A, Zambelli B, Macchiarulo A, Bellanda M, Battistutta R
J Struct Biol
. 2021 Mar;
213(2):107714.
PMID: 33667636
SLC26A5 transporter prestin is fundamental for the higher hearing sensitivity and frequency selectivity of mammals. Prestin is a voltage-dependent transporter found in the cochlear outer hair cells responsible for their...
8.
Dalle Vedove A, Zonta F, Zanforlin E, Demitri N, Ribaudo G, Cazzanelli G, et al.
Eur J Med Chem
. 2020 Apr;
195:112267.
PMID: 32283296
Protein kinase CK2 sustains cancer growth, especially in hematological malignancies. Its inhibitor SRPIN803, based on a 6-methylene-5-imino-1,3,4-thiadiazolopyrimidin-7-one scaffold, showed notable specificity. Our synthesis of the initially proposed SRPIN803 resulted in...
9.
Zamparo I, Francia S, Franchi S, Redolfi N, Costanzi E, Kerstens A, et al.
Cell Rep
. 2019 Dec;
29(13):4334-4348.e7.
PMID: 31875544
In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant...
10.
Cozza G, Zonta F, Dalle Vedove A, Venerando A, DallAcqua S, Battistutta R, et al.
FEBS J
. 2019 Oct;
287(9):1850-1864.
PMID: 31661600
Protein kinase CK2 is an antiapoptotic cancer-sustaining protein. Curcumin, reported previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2 active site and rapidly degrades in...