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Roberta Marongiu

Explore the profile of Roberta Marongiu including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Kelm-Nelson C, Brauer A, Barth K, Lake J, Sinnen M, Stehula F, et al.
Brain Res . 2017 Dec; 1680:1-12. PMID: 29229503
In Parkinson disease (PD), a complex neurodegenerative disorder that affects nearly 10 million people worldwide, motor skills are significantly impaired. However, onset and progression of motor deficits and the neural...
12.
Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci M, et al.
Proc Natl Acad Sci U S A . 2016 Jan; 113(5):1423-8. PMID: 26787858
Complications of dopamine replacement for Parkinson's disease (PD) can limit therapeutic options, leading to interest in identifying novel pathways that can be exploited to improve treatment. p11 (S100A10) is a...
13.
Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt M, Greengard P, et al.
Proc Natl Acad Sci U S A . 2016 Jan; 113(5):1429-34. PMID: 26787846
The reduced movement repertoire of Parkinson's disease (PD) is mainly due to degeneration of nigrostriatal dopamine neurons. Restoration of dopamine transmission by levodopa (L-DOPA) relieves motor symptoms of PD but...
14.
Gursel D, Banu M, Berry N, Marongiu R, Burkhardt J, Kobylarz K, et al.
J Neurooncol . 2014 Oct; 121(1):19-29. PMID: 25344882
Malignant gliomas represent one of the most aggressive forms of cancer, displaying high mortality rates and limited treatment options. Specific subpopulations of cells residing in the tumor niche with stem-like...
15.
Arango-Lievano M, Schwarz J, Vernov M, Wilkinson M, Bradbury K, Feliz A, et al.
Biol Psychiatry . 2014 Apr; 76(10):794-801. PMID: 24725970
Background: The high rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms and anatomical pathways. Limbic structures, such as the nucleus accumbens (NAc), play a crucial role...
16.
Morgenstern P, Marongiu R, Musatov S, Kaplitt M
Methods Mol Biol . 2011 Sep; 793:443-55. PMID: 21913118
The advent of viral gene therapy technology has contributed greatly to the study of a variety of medical conditions, and there is increasing promise for clinical translation of gene therapy...
17.
Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, et al.
J Neurochem . 2009 Jan; 108(6):1561-74. PMID: 19166511
Parkinson's disease (PD) is characterized by accumulation of alpha-synuclein (alpha-syn) and degeneration of neuronal populations in cortical and subcortical regions. Mitochondrial dysfunction has been considered a potential unifying factor in...
18.
Marongiu R, Ferraris A, Ialongo T, Michiorri S, Soleti F, Ferrari F, et al.
Hum Mutat . 2008 Mar; 29(4):565. PMID: 18330912
Heterozygous rare variants in the PINK1 gene, as well as in other genes causing autosomal recessive parkinsonism, have been reported both in patients and healthy controls. Their pathogenic significance is...
19.
Marongiu R, Brancati F, Antonini A, Ialongo T, Ceccarini C, Scarciolla O, et al.
Hum Mutat . 2006 Dec; 28(1):98. PMID: 17154281
Autosomal recessive parkinsonism is a genetic condition closely resembling Parkinson disease, the only distinguishing features being an earlier age at onset and a slower disease progression. Three causative genes have...
20.
Criscuolo C, Volpe G, De Rosa A, Varrone A, Marongiu R, Mancini P, et al.
Mov Disord . 2006 May; 21(8):1265-7. PMID: 16700027
We analyzed the PINK1 gene in 58 patients with early-onset Parkinsonism and detected the homozygous mutation W437X in 1 patient. The clinical phenotype was characterized by early onset (22 years...