Roberta D Brinton
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Explore the profile of Roberta D Brinton including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Karp J, Brinton R, Fournier J, Harding L, Jha M, Lenze E, et al.
J Clin Psychiatry
. 2024 Dec;
85(4).
PMID: 39630090
The pandemic refocused interest on the burden of depression across the lifespan; the increased efforts to prevent and treat depression are now a priority of health care systems, insurers, patient...
2.
Mi Y, Qi G, Vitali F, Shang Y, Raikes A, Wang T, et al.
Nat Metab
. 2023 Mar;
5(3):445-465.
PMID: 36959514
Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative phosphorylation (OxPhos) activity, but its pathophysiological role in neurodegeneration remains...
3.
Hernandez G, Brinton R
Neurobiol Stress
. 2022 Dec;
21:100502.
PMID: 36532370
Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of...
4.
Raikes A, Hernandez G, Mullins V, Wang Y, Lopez C, Killgore W, et al.
Front Neurol
. 2022 Oct;
13:891531.
PMID: 36188406
Context: Repetitive sub-concussive head impacts (RSHIs) are common in American football and result in changes to the microstructural integrity of white matter. Both docosahexaenoic acid (DHA) and eicosapentaoic acid (EPA)...
5.
Mullins V, Graham S, Cummings D, Wood A, Ovando V, Skulas-Ray A, et al.
Nutrients
. 2022 May;
14(10).
PMID: 35631280
There are limited studies on neuroprotection from repeated subconcussive head impacts (RSHI) following docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) supplementation in contact sports athletes. We performed a randomized, placebo-controlled,...
6.
Chang R, Trushina E, Zhu K, Zaidi S, Lau B, Kueider-Paisley A, et al.
Alzheimers Dement
. 2022 Apr;
19(2):518-531.
PMID: 35481667
Introduction: Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic profiles...
7.
Raikes A, Hernandez G, Matthews D, Lukic A, Law M, Shi Y, et al.
Alzheimers Dement (N Y)
. 2022 Mar;
8(1):e12258.
PMID: 35310526
Introduction: Allopregnanolone (ALLO), an endogenous neurosteroid, promoted neurogenesis and oligogenesis and restored cognitive function in animal models of Alzheimer's disease (AD). Based on these discovery research findings, we conducted a...
8.
Mishra A, Wang Y, Yin F, Vitali F, Rodgers K, Soto M, et al.
Ageing Res Rev
. 2021 Dec;
74:101542.
PMID: 34929348
Neurological aging is frequently viewed as a linear process of decline, whereas in reality, it is a dynamic non-linear process. The dynamic nature of neurological aging is exemplified during midlife...
9.
Hernandez G, Solinsky C, Mack W, Kono N, Rodgers K, Wu C, et al.
Alzheimers Dement (N Y)
. 2020 Dec;
6(1):e12107.
PMID: 33344752
Introduction: Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well-established preclinical safety efficacy make it...
10.
Mishra A, Shang Y, Wang Y, Bacon E, Yin F, Brinton R
iScience
. 2020 Dec;
23(12):101829.
PMID: 33319170
Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological...