Robert Zweigerdt
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Explore the profile of Robert Zweigerdt including associated specialties, affiliations and a list of published articles.
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106
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2925
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Recent Articles
1.
Demkes E, Cervera-Barea A, Ebner-Peking P, Wolf M, Hochmann S, Scheren A, et al.
J Cardiovasc Transl Res
. 2025 Mar;
PMID: 40082315
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) constitute a promising therapy for myocardial infarction (MI). The lack of an effective immunosuppressive regimen, combined with single-cell transplantations, results in suboptimal outcomes, such...
2.
Osten F, Bodenschatz A, Ivaskevica K, Krohn S, Piep B, Holler T, et al.
J Muscle Res Cell Motil
. 2025 Feb;
PMID: 39948277
To fully exploit the potential of human pluripotent stem cell-derived cardiomyocytes, ideally they should acquire a mature, adult ventricular-like phenotype. Predominant expression of the β-isoform of myosin heavy chain (β-MyHC)...
3.
Weber N, Montag J, Kowalski K, Iorga B, de la Roche J, Holler T, et al.
J Mol Cell Cardiol
. 2024 Dec;
198():112-125.
PMID: 39647438
Hypertrophic Cardiomyopathy (HCM) is often caused by heterozygous mutations in β-myosin heavy chain (MYH7, β-MyHC). In addition to hyper- or hypocontractile effects of HCM-mutations, heterogeneity in contractile function (contractile imbalance)...
4.
Hashemi M, Finklea F, Hammons H, Tian Y, Young N, Kim E, et al.
Bioact Mater
. 2024 Oct;
43:423-440.
PMID: 39399838
A reliable suspension-based platform for scaling engineered cardiac tissue (ECT) production from human induced pluripotent stem cells (hiPSCs) is crucial for regenerative therapies. Here, we compared the production and functionality...
5.
Dardano M, Kleemiss F, Kosanke M, Lang D, Wilson L, Franke A, et al.
Nat Cell Biol
. 2024 Oct;
26(11):1984-1996.
PMID: 39379702
Despite the biomedical importance of haematopoietic stem cells and haematopoietic progenitor cells, their in vitro stabilization in a developmental context has not been achieved due to limited knowledge of signals...
6.
Finklea F, Hashemi M, Tian Y, Hammons H, Halloin C, Triebert W, et al.
Biotechnol Bioeng
. 2024 Aug;
121(11):3614-3628.
PMID: 39104025
Chemically defined, suspension culture conditions are a key requirement in realizing clinical translation of engineered cardiac tissues (ECTs). Building on our previous work producing functional ECT microspheres through differentiation of...
7.
Kriedemann N, Manstein F, Hernandez-Bautista C, Ullmann K, Triebert W, Franke A, et al.
Stem Cell Res Ther
. 2024 Jul;
15(1):213.
PMID: 39020441
Background: Commonly used media for the differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs) contain high concentrations of proteins, in particular albumin, which is prone to quality variations and...
8.
Schneider A, Hage A, Stein I, Kriedemann N, Zweigerdt R, Leffler A
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928302
An accumulation of reactive oxygen species (ROS) in cardiomyocytes can induce pro-arrhythmogenic late Na currents by removing the inactivation of voltage-gated Na channels including the tetrodotoxin (TTX)-resistant cardiac α-subunit Nav1.5...
9.
Andree B, Voss N, Kriedemann N, Triebert W, Teske J, Mertens M, et al.
Sci Rep
. 2024 Jun;
14(1):13174.
PMID: 38849457
Due to its structural and functional complexity the heart imposes immense physical, physiological and electromechanical challenges on the engineering of a biological replacement. Therefore, to come closer to clinical translation,...
10.
Bolesani E, Bornhorst D, Iyer L, Zawada D, Friese N, Morgan M, et al.
Cardiovasc Res
. 2024 Jun;
120(11):1295-1311.
PMID: 38836637
Aims: Understanding the molecular identity of human pluripotent stem cell (hPSC)-derived cardiac progenitors and mechanisms controlling their proliferation and differentiation is valuable for developmental biology and regenerative medicine. Methods And...