Robert Witte
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Explore the profile of Robert Witte including associated specialties, affiliations and a list of published articles.
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15
Citations
168
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Recent Articles
1.
Ojha R, Jiang A, Mantyla E, Quirin T, Modhira N, Witte R, et al.
PLoS Pathog
. 2024 Nov;
20(11):e1012690.
PMID: 39541404
Mammalian receptor-mediated endocytosis (RME) often involves at least one of three isoforms of the large GTPase dynamin (Dyn). Dyn pinches-off vesicles at the plasma membrane and mediates uptake of many...
2.
Witte R, Kar S, Radacki K, Harterich M, Rang M, Michel M, et al.
Chem Commun (Camb)
. 2024 Jul;
60(65):8629-8632.
PMID: 39049809
The photolytic or oxidative liberation of a cyclic (amino)(alkyl)carbene (CAAC)-stabilized arylborylene in the presence of organoazides yielded borylene-organoazide complexes (4a,b) has been achieved in a manner akin to the first...
3.
Gartner A, Karaca U, Rang M, Heinz M, Engel P, Krummenacher I, et al.
J Am Chem Soc
. 2023 Mar;
145(14):8231-8241.
PMID: 36977310
We report a detailed computational and experimental study of the fixation and reductive coupling of dinitrogen with low-valent boron compounds. Consistent with our mechanistic findings, the selectivity toward nitrogen fixation...
4.
Witte R, Arrowsmith M, Lamprecht A, Schorr F, Krummenacher I, Braunschweig H
Chemistry
. 2022 Dec;
29(16):e202203663.
PMID: 36562195
A cyclic alkyl(amino)carbene (CAAC)-stabilized dicoordinate aminoborylene is synthesized by the twofold reduction of a [(CAAC)BCl (TMP)] (TMP=2,6-tetramethylpiperidyl) precursor. NMR-spectroscopic, X-ray crystallographic and computational analyses confirm the cumulenic nature of the...
5.
Olszewski D, Georgi F, Murer L, Andriasyan V, Kuttler F, Petkidis A, et al.
Sci Data
. 2022 Oct;
9(1):610.
PMID: 36209289
Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of...
6.
Andriasyan V, Yakimovich A, Petkidis A, Georgi F, Witte R, Puntener D, et al.
iScience
. 2021 Jun;
24(6):102543.
PMID: 34151222
Imaging across scales reveals disease mechanisms in organisms, tissues, and cells. Yet, particular infection phenotypes, such as virus-induced cell lysis, have remained difficult to study. Here, we developed imaging modalities...
7.
Rang M, Fantuzzi F, Arrowsmith M, Krummenacher I, Beck E, Witte R, et al.
Angew Chem Int Ed Engl
. 2020 Nov;
60(6):2963-2968.
PMID: 33191596
The one-electron reduction of a cyclic (alkyl)(amino)carbene (CAAC)-stabilized arylborylene carbonyl complex yields a dimeric borylketyl radical anion, resulting from an intramolecular aryl migration to the CO carbon atom. Computational analyses...
8.
A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Georgi F, Kuttler F, Murer L, Andriasyan V, Witte R, Yakimovich A, et al.
Sci Data
. 2020 Aug;
7(1):265.
PMID: 32788590
Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral...
9.
Georgi F, Andriasyan V, Witte R, Murer L, Hemmi S, Yu L, et al.
Antimicrob Agents Chemother
. 2020 Jul;
64(9).
PMID: 32601166
Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. Human AdV (HAdV) species B and C, such as HAdV-C2, -C5, and -B14, cause respiratory disease and constitute...
10.
Yakimovich A, Witte R, Andriasyan V, Georgi F, Greber U
mSphere
. 2018 Nov;
3(6).
PMID: 30463927
Cytopathic effects (CPEs) are a hallmark of infections. CPEs are difficult to observe due to phototoxicity from classical light microscopy. We report distinct patterns of virus infections in live cells...