Lindsey A Muir
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Explore the profile of Lindsey A Muir including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Cwycyshyn J, Stansbury C, Meixner W, Hoying J, Muir L, Rajapakse I
APL Bioeng
. 2024 Oct;
8(4):046106.
PMID: 39479200
The advent of advanced robotic platforms and workflow automation tools has revolutionized the landscape of biological research, offering unprecedented levels of precision, reproducibility, and versatility in experimental design. In this...
2.
Stansbury C, Dotson G, Pugh H, Rehemtulla A, Rajapakse I, Muir L
JCI Insight
. 2023 Aug;
8(19).
PMID: 37651193
Adipose tissue macrophage (ATM) infiltration is associated with adipose tissue dysfunction and insulin resistance in mice and humans. Recent single-cell data highlight increased ATM heterogeneity in obesity but do not...
3.
Dotson G, Chen C, Lindsly S, Cicalo A, Dilworth S, Ryan C, et al.
Nat Commun
. 2022 Sep;
13(1):5498.
PMID: 36127324
Chromatin architecture, a key regulator of gene expression, can be inferred using chromatin contact data from chromosome conformation capture, or Hi-C. However, classical Hi-C does not preserve multi-way contacts. Here...
4.
Sun Y, Dotson G, Muir L, Ronquist S, Oravecz-Wilson K, Peltier D, et al.
iScience
. 2022 Aug;
25(9):104846.
PMID: 36043052
WAPL, cohesin's DNA release factor, regulates three-dimensional (3D) chromatin architecture. The 3D chromatin structure and its relevance to mature T cell functions is not well understood. We show that lymphopenic...
5.
Muir L, Cho K, Geletka L, Baker N, Flesher C, Ehlers A, et al.
JCI Insight
. 2022 Jan;
7(3).
PMID: 34990410
Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in humans and are causal in development of insulin resistance in mice. Recent bulk and single-cell transcriptomics studies reveal a wide...
6.
Song J, Frieler R, Whitesall S, Chung Y, Vigil T, Muir L, et al.
Am J Physiol Heart Circ Physiol
. 2020 Nov;
320(1):H323-H337.
PMID: 33164548
Interleukin-4 receptor α (IL4Rα) signaling plays an important role in cardiac remodeling during myocardial infarction (MI). However, the target cell type(s) of IL4Rα signaling during this remodeling remains unclear. Here,...
7.
Ludzki A, Krueger E, Baldwin T, Schleh M, Porsche C, Ryan B, et al.
Front Physiol
. 2020 Aug;
11:903.
PMID: 32848853
Adipose tissue pathology in obese patients often features impaired adipogenesis, angiogenesis, and chronic low-grade inflammation, all of which are regulated in large part by adipose tissue stromal vascular cells [SVC;...
8.
Zamarron B, Porsche C, Luan D, Lucas H, Mergian T, Martinez-Santibanez G, et al.
Obesity (Silver Spring)
. 2020 Apr;
28(6):1086-1097.
PMID: 32281747
Objective: Weight regain after weight loss is common, and there is evidence to suggest negative effects on health because of weight cycling. This study sought to investigate the impact of...
9.
Liu S, Chen H, Ronquist S, Seaman L, Ceglia N, Meixner W, et al.
iScience
. 2018 Sep;
6:232-246.
PMID: 30240614
Genome architecture has emerged as a critical element of transcriptional regulation, although its role in the control of cell identity is not well understood. Here we use transcription factor (TF)-mediated...
10.
Muir L, Kiridena S, Griffin C, Delproposto J, Geletka L, Martinez-Santibanez G, et al.
J Leukoc Biol
. 2018 Mar;
103(4):615-628.
PMID: 29493813
Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We...