Robert Vacha
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Explore the profile of Robert Vacha including associated specialties, affiliations and a list of published articles.
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Articles
76
Citations
980
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Recent Articles
31.
Prochazkova M, Fuzik T, Grybchuk D, Falginella F, Podesvova L, Yurchenko V, et al.
J Virol
. 2020 Nov;
95(3).
PMID: 33208443
parasites cause a variety of symptoms, including mucocutaneous leishmaniasis, which results in the destruction of the mucous membranes of the nose, mouth, and throat. The species of carrying RNA virus...
32.
Brozek R, Kabelka I, Vacha R
J Phys Chem B
. 2020 Jul;
124(28):5940-5947.
PMID: 32603116
Biological membranes present a major obstacle for the delivery of therapeutic agents into cells. Some peptides have been shown to translocate across the membrane spontaneously, and they could be thus...
33.
Brazda P, Krejcikova M, Kasiliauskaite A, Smirakova E, Klumpler T, Vacha R, et al.
J Mol Biol
. 2020 May;
432(14):4092-4107.
PMID: 32439331
Transcription elongation factor Spt6 associates with RNA polymerase II (RNAP II) via a tandem SH2 (tSH2) domain. The mechanism and significance of the RNAP II-Spt6 interaction is still unclear. Recently,...
34.
Tuerkova A, Kabelka I, Kralova T, Sukenik L, Pokorna S, Hof M, et al.
Elife
. 2020 Mar;
9.
PMID: 32167466
Every cell is protected by a semipermeable membrane. Peptides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores. Unfortunately, matching...
35.
Kabelka I, Pachler M, Prevost S, Letofsky-Papst I, Lohner K, Pabst G, et al.
Biophys J
. 2020 Jan;
118(3):612-623.
PMID: 31952806
We studied the synergistic mechanism of equimolar mixtures of magainin 2 (MG2a) and PGLa in phosphatidylethanolamine/phosphatidylglycerol mimics of Gram-negative cytoplasmic membranes. In a preceding article of this series, we reported...
36.
Jurasek M, Flardh K, Vacha R
Biochim Biophys Acta Biomembr
. 2019 Dec;
1862(8):183144.
PMID: 31821790
DivIVA is a crucial membrane-binding protein that helps to localize other proteins to negatively curved membranes at cellular poles and division septa in Gram-positive bacteria. The N-terminal domain of DivIVA...
37.
Pachler M, Kabelka I, Appavou M, Lohner K, Vacha R, Pabst G
Biophys J
. 2019 Nov;
117(10):1858-1869.
PMID: 31703802
We addressed the onset of synergistic activity of the two well-studied antimicrobial peptides magainin 2 (MG2a) and PGLa using lipid-only mimics of Gram-negative cytoplasmic membranes. Specifically, we coupled a joint...
38.
Owen M, Karner A, Sachl R, Preiner J, Amaro M, Vacha R
J Phys Chem B
. 2019 Aug;
123(35):7504-7517.
PMID: 31397569
The great physiological relevance of glycolipids is being increasingly recognized, and glycolipid interactions have been shown to be central to cell-cell recognition, neuronal plasticity, protein-ligand recognition, and other important processes....
39.
Harnos J, Canizal M, Jurasek M, Kumar J, Holler C, Schambony A, et al.
Nat Commun
. 2019 Apr;
10(1):1804.
PMID: 31000703
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin...
40.
Buchta D, Fuzik T, Hrebik D, Levdansky Y, Sukenik L, Mukhamedova L, et al.
Nat Commun
. 2019 Mar;
10(1):1138.
PMID: 30850609
Viruses from the genus Enterovirus are important human pathogens. Receptor binding or exposure to acidic pH in endosomes converts enterovirus particles to an activated state that is required for genome...