Robert T Elder
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Explore the profile of Robert T Elder including associated specialties, affiliations and a list of published articles.
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16
Citations
239
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Recent Articles
1.
Benko Z, Liang D, Li G, Elder R, Sarkar A, Takayama J, et al.
Cell Biosci
. 2017 Jan;
7:5.
PMID: 28096973
Background: HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful...
2.
Benko Z, Elder R, Li G, Liang D, Zhao R
PLoS One
. 2016 Mar;
11(3):e0151286.
PMID: 26982200
Background: HIV-1 protease (PR) is an essential viral enzyme. Its primary function is to proteolyze the viral Gag-Pol polyprotein for production of viral enzymes and structural proteins and for maturation...
3.
Gazdag Z, Stromajer-Racz T, Belagyi J, Zhao R, Elder R, Virag E, et al.
Acta Biol Hung
. 2015 Sep;
66(3):326-38.
PMID: 26344028
The wild-type viral protein R (Vpr) of human immunodeficiency virus type 1 exerts multiple effects on cellular activities during infection, including the induction of cell cycle G2 arrest and the...
4.
Li G, Elder R, Dubrovsky L, Liang D, Pushkarsky T, Chiu K, et al.
PLoS One
. 2010 Jul;
5(6):e11371.
PMID: 20614012
HIV-1 Vpr is a virion-associated protein. Its activities link to viral pathogenesis and disease progression of HIV-infected patients. In vitro, Vpr moderately activates HIV-1 replication in proliferating T cells, but...
5.
Huard S, Chen M, Burdette K, Fenyvuesvolgyi C, Yu M, Elder R, et al.
Cell Res
. 2009 Jan;
18(9):961-73.
PMID: 19160543
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell death in mammalian and fission yeast cells, suggesting that Vpr may affect a conserved cellular process. It is unclear, however, whether...
6.
Huard S, Elder R, Liang D, Li G, Zhao R
J Virol
. 2007 Dec;
82(6):2904-17.
PMID: 18160429
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle G(2) arrest in fission yeast (Schizosaccharomyces pombe) and mammalian cells, suggesting the cellular pathway(s) targeted by Vpr is conserved among...
7.
Zhao R, Elder R, Bukrinsky M
Adv Pharmacol
. 2007 Jun;
55:233-60.
PMID: 17586317
No abstract available.
8.
Li G, Elder R, Qin K, Park H, Liang D, Zhao R
J Biol Chem
. 2007 Jan;
282(10):7287-98.
PMID: 17210576
ATM and Rad3-related (ATR) is a regulatory kinase that, when activated by hydroxyurea, UV, or human immunodeficiency virus-1 Vpr, causes cell cycle arrest through Chk1-Ser(345) phosphorylation. We demonstrate here that...
9.
Fenyvuesvolgyi C, Elder R, Benko Z, Liang D, Zhao R
Biochim Biophys Acta
. 2005 Nov;
1746(2):155-62.
PMID: 16297994
A fission yeast (Schizosaccharomyces pombe) gene encoding a member of the TIP41-like protein family was identified and characterized. Deletion of the fission yeast tip41 gene leads to slower growth when...
10.
Zhao R, Bukrinsky M, Elder R
Indian J Med Res
. 2005 Apr;
121(4):270-86.
PMID: 15817944
During infection of host cells by HIV-1, active host-pathogen interactions take place. The final balance between these interactions determines the efficiency of viral infection and subsequent disease progression. HIV-infected cells...