Robert Safirstein
Overview
Explore the profile of Robert Safirstein including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
438
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0
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Recent Articles
1.
Tang C, Livingston M, Safirstein R, Dong Z
Nat Rev Nephrol
. 2022 Oct;
19(1):53-72.
PMID: 36229672
Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause acute...
2.
Wang Y, Li F, Chu C, Zhang X, Zhang X, Liao Y, et al.
EClinicalMedicine
. 2022 May;
48:101420.
PMID: 35516445
Background: Albuminuria is a marker of vascular dysfunction and is associated with chronic renal and cardiovascular diseases. Data on the association between the longitudinal patterns of weight change early in...
3.
Safdar B, Wang M, Guo X, Cha C, Chun H, Deng Y, et al.
PLoS One
. 2022 Mar;
17(3):e0264178.
PMID: 35259186
Renalase is a secreted flavoprotein with anti-inflammatory and pro-cell survival properties. COVID-19 is associated with disordered inflammation and apoptosis. We hypothesized that blood renalase levels would correspond to severe COVID-19...
4.
Guo X, Jessel S, Qu R, Kluger Y, Chen T, Hollander L, et al.
Eur J Cancer
. 2022 Feb;
165:81-96.
PMID: 35219026
Background: Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in...
5.
Guo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, et al.
J Am Soc Nephrol
. 2021 Dec;
33(2):342-356.
PMID: 34921111
Background: Repeated administration of cisplatin causes CKD. In previous studies, we reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide protected mice from cisplatin-induced AKI. Methods: To...
6.
Wang Y, Du M, Yao S, Zou T, Zhang X, Hu G, et al.
Front Cardiovasc Med
. 2021 Dec;
8:710023.
PMID: 34869624
Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic...
7.
Safirstein R
J Clin Invest
. 2021 Mar;
131(5).
PMID: 33645547
Tubulointerstitial accumulation of matrix proteins in human kidney biopsies is the best predictor of renal survival. In this issue of the JCI, Yen-Ting Chen et al. elegantly show that an...
8.
Landau S, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, et al.
Kidney Int
. 2019 Mar;
95(4):797-814.
PMID: 30904067
Cisplatin is an effective chemotherapeutic agent, but significant nephrotoxicity limits its clinical use. Despite extensive investigation of the acute cellular and molecular responses to cisplatin, the mechanisms of progression from...
9.
Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, et al.
J Cell Mol Med
. 2017 Feb;
21(7):1260-1265.
PMID: 28238213
Renalase was discovered as a protein synthesized by the kidney and secreted in blood where it circulates at a concentration of approximately 3-5 μg/ml. Initial reports suggested that it functioned...
10.
Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, et al.
Cancer Res
. 2016 May;
76(13):3884-94.
PMID: 27197188
To sustain their proliferation, cancer cells overcome negative-acting signals that restrain their growth and promote senescence and cell death. Renalase (RNLS) is a secreted flavoprotein that functions as a survival...