Robert S Adelstein
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Explore the profile of Robert S Adelstein including associated specialties, affiliations and a list of published articles.
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78
Citations
5393
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Recent Articles
1.
Sung D, Ahmad M, Lerma Cervantes C, Zhang Y, Adelstein R, Ma X
Dev Biol
. 2020 Nov;
470:49-61.
PMID: 33188738
Mutations in non-muscle myosin 2A (NM2A) encompass a wide spectrum of anomalies collectively known as MYH9-Related Disease (MYH9-RD) in humans that can include macrothrombocytopenia, glomerulosclerosis, deafness, and cataracts. We previously...
2.
Ma X, Uchida Y, Wei T, Liu C, Adams R, Kubota Y, et al.
Mol Biol Cell
. 2020 Jun;
31(18):1974-1987.
PMID: 32583739
Among the three nonmuscle myosin 2 (NM2) paralogs, NM 2A and 2B, but not 2C, are detected in endothelial cells. To study the role of NM2 in vascular formation, we...
3.
Tan L, Hu Y, Li Y, Yang L, Cai X, Liu W, et al.
PLoS One
. 2020 Apr;
15(3):e0230126.
PMID: 32226034
The generation of genetically modified mouse models derived from gene targeting (GT) in mouse embryonic stem (ES) cells (mESCs) has greatly advanced both basic and clinical research. Our previous finding...
4.
Zhovmer A, Tabdanov E, Miao H, Wen H, Chen J, Luo X, et al.
Mol Biol Cell
. 2019 Jul;
30(16):1961-1973.
PMID: 31318315
Contact guidance refers to the ability of cells to sense the geometrical features of the microenvironment and respond by changing their shape and adopting the appropriate orientation. Inhibition and ablation...
5.
Acebedo A, Suzuki K, Hino S, Alcantara M, Sato Y, Haga H, et al.
Commun Biol
. 2019 Mar;
2:95.
PMID: 30886905
The morphogenesis of mammalian embryonic external genitalia (eExG) shows dynamic differences between males and females. In genotypic males, eExG are masculinized in response to androgen signaling. Disruption of this process...
6.
Kim H, Yin W, Jin Y, Panza P, Gunawan F, Grohmann B, et al.
Nat Commun
. 2018 Nov;
9(1):4600.
PMID: 30389913
Impaired alveolar formation and maintenance are features of many pulmonary diseases that are associated with significant morbidity and mortality. In a forward genetic screen for modulators of mouse lung development,...
7.
Zhang Y, Liu C, Adelstein R, Ma X
Mol Biol Cell
. 2018 Jul;
29(19):2326-2335.
PMID: 30044719
Three paralogues of nonmuscle myosin 2 (NM 2A, 2B, and 2C) are expressed in mammals, and the heavy chains are the products of three different genes (Myh9, Myh10, and Myh14,...
8.
Pecci A, Ma X, Savoia A, Adelstein R
Gene
. 2018 Apr;
664:152-167.
PMID: 29679756
The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the generation of intracellular chemomechanical force...
9.
Masedunskas A, Appaduray M, Lucas C, Cagigas M, Heydecker M, Holliday M, et al.
J Cell Sci
. 2018 Mar;
131(6).
PMID: 29487177
Many actin filaments in animal cells are co-polymers of actin and tropomyosin. In many cases, non-muscle myosin II associates with these co-polymers to establish a contractile network. However, the temporal...
10.
Liu T, Hu Y, Guo S, Tan L, Zhan Y, Yang L, et al.
PLoS One
. 2018 Feb;
13(2):e0192641.
PMID: 29438440
Targeted integration of exogenous genes into so-called safe harbors/friend sites, offers the advantages of expressing normal levels of target genes and preventing potentially adverse effects on endogenous genes. However, the...