Robert N Mames
Overview
Explore the profile of Robert N Mames including associated specialties, affiliations and a list of published articles.
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13
Citations
635
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Recent Articles
1.
Kielczewski J, Li Calzi S, Shaw L, Cai J, Qi X, Ruan Q, et al.
Invest Ophthalmol Vis Sci
. 2011 Sep;
52(11):8278-86.
PMID: 21931131
Purpose: To examine the effect of free insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), independent of the effect of insulin-like growth factors, in modulating retinal vascular permeability. Methods: We assessed...
2.
Kielczewski J, Hu P, Shaw L, Li Calzi S, Mames R, Gardiner T, et al.
Am J Pathol
. 2011 Mar;
178(4):1517-28.
PMID: 21435441
This study was conducted to determine the perivascular cell responses to increased endothelial cell expression of insulin-like growth factor binding protein-3 (IGFBP-3) in mouse retina. The contribution of bone marrow...
3.
Kielczewski J, Jarajapu Y, McFarland E, Cai J, Afzal A, Li Calzi S, et al.
Circ Res
. 2009 Sep;
105(9):897-905.
PMID: 19762684
Rationale: Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism...
4.
Ellis E, Sengupta N, Caballero S, Guthrie S, Mames R, Grant M
Antioxid Redox Signal
. 2005 Dec;
7(11-12):1413-22.
PMID: 16356104
We used knockout animals of either inducible nitric oxide synthase (iNOS(/)) or endothelial NOS (eNOS(/)) to characterize the role of NOS in galactosemia, a model of diabetic retinopathy. NADH oxidase...
5.
Butler J, Guthrie S, Koc M, Afzal A, Caballero S, Brooks H, et al.
J Clin Invest
. 2005 Jan;
115(1):86-93.
PMID: 15630447
Diabetic retinopathy is the leading cause of blindness in working-age adults. It is caused by oxygen starvation in the retina inducing aberrant formation of blood vessels that destroy retinal architecture....
6.
Sengupta N, Caballero S, Mames R, Timmers A, Saban D, Grant M
Invest Ophthalmol Vis Sci
. 2004 Dec;
46(1):343-8.
PMID: 15623794
Purpose: The primary cause of vision loss in people more than 50 years of age in developed nations is age-related macular degeneration (ARMD). The wet form of ARMD is characterized...
7.
Guthrie S, Curtis L, Mames R, Simon G, Grant M, Scott E
Blood
. 2004 Nov;
105(5):1916-22.
PMID: 15546953
We have previously established a model inducing hematopoietic stem cell (HSC) production of circulating endothelial progenitor cells (EPCs) to revascularize ischemic injury in adult mouse retina. The unique vascular environment...
8.
Guthrie S, Caballero S, Mames R, Grant M, Scott E
Methods Mol Med
. 2004 Oct;
105:369-80.
PMID: 15492408
The hematopoietic stem cells residing in the bone marrow have tremendous proliferative and self-renewing capacity, and until recently these cells were thought to produce only progeny of the blood lineages....
9.
Grant M, Afzal A, Spoerri P, Pan H, Shaw L, Mames R
Expert Opin Investig Drugs
. 2004 Oct;
13(10):1275-93.
PMID: 15461557
Diabetic retinopathy (DR) is the most severe of several ocular complications of diabetes. The earliest clinical signs of DR are microaneurysms and haemorrhages. Later signs include dilated, tortuous irregular veins...
10.
Sengupta N, Caballero S, Mames R, Butler J, Scott E, Grant M
Invest Ophthalmol Vis Sci
. 2003 Oct;
44(11):4908-13.
PMID: 14578416
Purpose: Age-related macular degeneration (ARMD) is the primary cause of blindness in people aged of 50 years or more. The wet form leads to severe loss of central vision. Recent...