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Robert Mantei

Explore the profile of Robert Mantei including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 73
Followers 0
Related Specialties
Biochemistry
Chemistry
Top 10 Co-Authors
Vered Klinghofer
Kent Stewart
Vincent L Giranda
Todd W Rockway
Xumiao Zhao
Andrew Geyer
Moshe Weitzberg
Michael D Wendt
Vicki L Nienaber
William J McClellan
Published In
Bioorg Med Chem Lett
J Med Chem
ACS Med Chem Lett
Affiliations
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Recent Articles
1.
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Michaelides M, Kluge A, Patane M, Van Drie J, Wang C, Hansen T, et al.
ACS Med Chem Lett . 2018 Jan; 9(1):28-33. PMID: 29348807
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel,...
2.
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze S, Erickson S, Wang G, Mantei R, Clark R, Sorensen B, et al.
Bioorg Med Chem Lett . 2010 Mar; 20(8):2452-5. PMID: 20346655
The design and enzyme activities of a novel class of imidazo[2,1-b]thiazoles is presented.
3.
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties
Bruncko M, McClellan W, Wendt M, Sauer D, Geyer A, Dalton C, et al.
Bioorg Med Chem Lett . 2004 Dec; 15(1):93-8. PMID: 15582418
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
4.
Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors
Wendt M, Geyer A, McClellan W, Rockway T, Weitzberg M, Zhao X, et al.
Bioorg Med Chem Lett . 2004 May; 14(12):3063-8. PMID: 15149645
Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or unsaturated rings improved inhibitor performance; substitution with sulfones further improved...
5.
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution
Wendt M, Rockway T, Geyer A, McClellan W, Weitzberg M, Zhao X, et al.
J Med Chem . 2004 Jan; 47(2):303-24. PMID: 14711304
The preparation and assessment of biological activity of 6-substituted 2-naphthamidine inhibitors of the serine protease urokinase plasminogen activator (uPA, or urokinase) is described. 2-Naphthamidine was chosen as a starting point...