Robert M Stephens
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Explore the profile of Robert M Stephens including associated specialties, affiliations and a list of published articles.
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62
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5658
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Recent Articles
1.
Yi M, Nissley D, McCormick F, Stephens R
Sci Rep
. 2020 Jun;
10(1):10258.
PMID: 32581224
For nearly a decade, the difficulties associated with both the determination and reproducibility of Ras-dependency indexes (RDIs) have limited their application and further delineation of the biology underlying Ras dependency....
2.
Rabara D, Tran T, Dharmaiah S, Stephens R, McCormick F, Simanshu D, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(44):22122-22131.
PMID: 31611389
mutations occur in ∼35% of colorectal cancers and promote tumor growth by constitutively activating the mitogen-activated protein kinase (MAPK) pathway. mutations at codons 12, 13, or 61 are thought to...
3.
Yi M, Zhu R, Stephens R
PLoS One
. 2018 Dec;
13(12):e0207590.
PMID: 30517129
Accurate assessment of the association between continuous variables such as gene expression and survival is a critical aspect of precision medicine. In this report, we provide a review of some...
4.
Tang W, Wallace T, Yi M, Magi-Galluzzi C, Dorsey T, Onabajo O, et al.
Clin Cancer Res
. 2018 Jul;
24(21):5471-5481.
PMID: 30012562
Men of African ancestry experience an excessive prostate cancer mortality that could be related to an aggressive tumor biology. We previously described an immune-inflammation signature in prostate tumors of African-American...
5.
Stephens R, Yi M, Kessing B, Nissley D, McCormick F
Cancer Inform
. 2017 Jun;
16:1176935117711944.
PMID: 28634423
The 3 human RAS genes play pivotal roles regulating proliferation, differentiation, and survival in normal cells and become mutated in 15% to 20% of all human tumors and amplified in...
6.
Ye X, Chan K, Waters A, Bess M, Harned A, Wei B, et al.
Oncotarget
. 2016 Nov;
7(52):86948-86971.
PMID: 27894102
Oncogenic Ras mutants play a major role in the etiology of most aggressive and deadly carcinomas in humans. In spite of continuous efforts, effective pharmacological treatments targeting oncogenic Ras isoforms...
7.
Prueitt R, Wallace T, Glynn S, Yi M, Tang W, Luo J, et al.
Cancer Res
. 2016 Jan;
76(5):1055-1065.
PMID: 26719530
Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and...
8.
Temiz N, Donohue D, Bacolla A, Vasquez K, Cooper D, Mudunuri U, et al.
Hum Genet
. 2015 Jun;
134(8):865-7.
PMID: 26071096
No abstract available.
9.
Temiz N, Donohue D, Bacolla A, Vasquez K, Cooper D, Mudunuri U, et al.
Hum Genet
. 2015 May;
134(8):851-64.
PMID: 26001532
DNA damage in somatic cells originates from both environmental and endogenous sources, giving rise to mutations through multiple mechanisms. When these mutations affect the function of critical genes, cancer may...
10.
Yi M, Zhao Y, Jia L, He M, Kebebew E, Stephens R
Nucleic Acids Res
. 2014 May;
42(12):e101.
PMID: 24831545
To apply exome-seq-derived variants in the clinical setting, there is an urgent need to identify the best variant caller(s) from a large collection of available options. We have used an...