Robert M Niven
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Explore the profile of Robert M Niven including associated specialties, affiliations and a list of published articles.
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31
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1332
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Recent Articles
1.
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma
Busby J, Matthews J, Chaudhuri R, Pavord I, Hardman T, Arron J, et al.
Eur Respir J
. 2021 Sep;
59(4).
PMID: 34561291
Background: Understanding why patients with severe asthma do not follow healthcare provider (HCP) advice to adjust treatment is critical to achieving personalised disease management. Methods: We reviewed patient choice to...
2.
Heaney L, Busby J, Hanratty C, Djukanovic R, Woodcock A, Walker S, et al.
Lancet Respir Med
. 2020 Sep;
9(1):57-68.
PMID: 32916135
Background: Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driven eosinophilic...
3.
Maltby S, McDonald V, Upham J, Bowler S, Chung L, Denton E, et al.
Intern Med J
. 2020 Feb;
51(2):169-180.
PMID: 32104958
Severe asthma imposes a significant burden on individuals, families and the healthcare system. Treatment is complex, due to disease heterogeneity, comorbidities and complexity in care pathways. New approaches and treatments...
4.
Burn J, Sims A, Patrick H, Heaney L, Niven R
BMJ Open
. 2019 Jun;
9(6):e026742.
PMID: 31221880
Objectives: Use data from the UK Severe Asthma Registry (UKSAR) to assess the efficacy and safety of bronchial thermoplasty (BT) in routine UK clinical practice and to identify characteristics of...
5.
Patel D, Peiro T, Shoemark A, Akthar S, Walker S, Grabiec A, et al.
Sci Transl Med
. 2018 Aug;
10(455).
PMID: 30135247
It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence the development and progression of chronic diseases. The enzyme leukotriene A hydrolase (LTAH) mediates opposing proinflammatory and...
6.
Hanratty C, Matthews J, Arron J, Choy D, Pavord I, Bradding P, et al.
Trials
. 2018 Jan;
19(1):5.
PMID: 29301585
Background: Patients with difficult-to-control asthma consume 50-60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all...
7.
Niven R, Simmonds M, Cangelosi M, Tilden D, Cottrell S, Shargill N
J Asthma
. 2017 Jul;
55(4):443-451.
PMID: 28708944
Objective: Bronchial thermoplasty (BT) as an add-on therapy for uncontrolled severe asthma is an alternative to biologic therapies like omalizumab (OM). We conducted an indirect treatment comparison (ITC) to appraise...
8.
Grabiec A, Denny N, Doherty J, Happonen K, Hankinson J, Connolly E, et al.
J Allergy Clin Immunol
. 2017 Apr;
140(4):1144-1146.e4.
PMID: 28412392
No abstract available.
9.
Burn J, Sims A, Keltie K, Patrick H, Welham S, Heaney L, et al.
J Asthma
. 2016 Dec;
54(8):872-879.
PMID: 27905828
Objective: Bronchial thermoplasty (BT) is a novel treatment for severe asthma. Its mode of action and ideal target patient group remain poorly defined, though clinical trials provided some evidence on...
10.
Niven R, Saralaya D, Chaudhuri R, Masoli M, Clifton I, Mansur A, et al.
BMJ Open
. 2016 Aug;
6(8):e011857.
PMID: 27507234
Objective: To describe the impact of omalizumab on asthma management in patients treated as part of normal clinical practice in the UK National Health Service (NHS). Design: A non-interventional, mixed...