Robert M Kotin
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Explore the profile of Robert M Kotin including associated specialties, affiliations and a list of published articles.
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42
Citations
1853
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Recent Articles
1.
Destro F, Joseph J, Srinivasan P, Kanter J, Neufeld C, Wolfrum J, et al.
Mol Ther Methods Clin Dev
. 2023 Sep;
30:122-146.
PMID: 37746245
Current manufacturing processes for recombinant adeno-associated viruses (rAAVs) have less-than-desired yields and produce significant amounts of empty capsids. The increasing demand and the high cost of goods for rAAV-based gene...
2.
Campbell M, Loncar S, Kotin R, Gifford R
PLoS Biol
. 2022 Nov;
20(11):e3001867.
PMID: 36445931
Parvoviruses (family Parvoviridae) are small DNA viruses that cause numerous diseases of medical, veterinary, and agricultural significance and have important applications in gene and anticancer therapy. DNA sequences derived from...
3.
Hildebrandt E, Penzes J, Gifford R, Agbandje-Mckenna M, Kotin R
Virus Evol
. 2020 Sep;
6(2):veaa043.
PMID: 32913662
Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into host genomes millions of years ago and retained as heritable elements passed on to offspring until present-day....
4.
5.
Kotin R, Snyder R
Hum Gene Ther
. 2017 Mar;
28(4):350-360.
PMID: 28351174
Recombinant adeno-associated virus (rAAV) vectors are proving to be a reliable gene transfer system for several clinical applications, with an increasing body of evidence supporting safety and efficacy. Realizing the...
6.
Smith R, Hallwirth C, Westerman M, Hetherington N, Tseng Y, Cecchini S, et al.
Sci Rep
. 2016 Jul;
6:28965.
PMID: 27377618
Germline endogenous viral elements (EVEs) genetically preserve viral nucleotide sequences useful to the study of viral evolution, gene mutation, and the phylogenetic relationships among host organisms. Here, we describe a...
7.
Choudhury S, Fitzpatrick Z, Harris A, Maitland S, Ferreira J, Zhang Y, et al.
Mol Ther
. 2016 Apr;
24(7):1247-57.
PMID: 27117222
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of neurological disorders. Achieving global gene delivery to the central nervous system (CNS) is key for development...
8.
Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud J, et al.
Mol Ther
. 2014 Sep;
22(11):1923-35.
PMID: 25200009
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder caused by mutations in the dystrophin gene, without curative treatment yet available. Our study provides, for the first time, the overall...
9.
Li L, Dimitriadis E, Yang Y, Li J, Yuan Z, Qiao C, et al.
PLoS One
. 2013 Aug;
8(8):e69879.
PMID: 23936358
Conventional non-viral gene transfer uses bacterial plasmid DNA containing antibiotic resistance genes, cis-acting bacterial sequence elements, and prokaryotic methylation patterns that may adversely affect transgene expression and vector stability in...
10.
Airenne K, Hu Y, Kost T, Smith R, Kotin R, Ono C, et al.
Mol Ther
. 2013 Feb;
21(4):739-49.
PMID: 23439502
Insect-derived baculoviruses have emerged as versatile and safe workhorses of biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop and forest protection, as well as safe tools for...