Robert L Lester
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Explore the profile of Robert L Lester including associated specialties, affiliations and a list of published articles.
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10
Citations
430
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Recent Articles
1.
Lester R, Withers B, Schultz M, Dickson R
Biochim Biophys Acta
. 2013 Jan;
1831(4):726-36.
PMID: 23286903
Survival of Saccharomyces cerevisiae cells, like most microorganisms, requires switching from a rapidly dividing to a non-dividing or stationary state. To further understand how cells navigate this switch, we examined...
2.
Brace J, Lester R, Dickson R, Rudin C
Genetics
. 2006 Oct;
175(1):65-76.
PMID: 17057230
Sphingolipid signaling plays an important role in the regulation of central cellular processes, including cell growth, survival, and differentiation. Many of the essential pathways responsible for sphingolipid biogenesis, and key...
3.
Dickson R, Sumanasekera C, Lester R
Prog Lipid Res
. 2006 May;
45(6):447-65.
PMID: 16730802
We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly...
4.
Liu K, Zhang X, Lester R, Dickson R
J Biol Chem
. 2005 Apr;
280(24):22679-87.
PMID: 15840588
The Pkh1 protein kinase of Saccharomyces cerevisiae, a homolog of the mammalian 3-phosphoinositide-dependent kinase (PDK1), regulates downstream AGC-type protein kinases including Ypk1/2 and Pkc1, which control cell wall integrity, growth,...
5.
Zhang X, Lester R, Dickson R
J Biol Chem
. 2004 Mar;
279(21):22030-8.
PMID: 15016821
The Saccharomyces cerevisiae homologs, Pkh1/2p, of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1) regulate the Pkc1-MAP kinase cascade and the partially parallel Ypk1/2p pathway(s) that control growth and cell integrity....
6.
Chung J, Lester R, Dickson R
J Biol Chem
. 2003 May;
278(31):28872-81.
PMID: 12746460
There has been no previous indication that vacuolar ATPases (V-ATPases) require sphingolipids for function. Here we show, by using Saccharomyces cerevisiae sur4Delta and fen1Delta cells, that sphingolipids with a C26...
7.
Hait N, Fujita K, Lester R, Dickson R
FEBS Lett
. 2002 Dec;
532(1-2):97-102.
PMID: 12459470
Sphingoid long chain base phosphates (LCBPs) regulate cell proliferation, survival and motility in mammals. To learn more about LCBPs in Saccharomyces cerevisiae, we determined the cellular location of Lcb4p, the...
8.
Hearn J, Lester R, Dickson R
J Biol Chem
. 2002 Nov;
278(6):3679-86.
PMID: 12446707
Sphingolipids are abundant components of eucaryotic membranes, where they perform essential functions. To uncover new roles for sphingolipids, we studied Saccharomyces cerevisiae lcb1-100 cells, which have a temperature-sensitive block in...
9.
Dickson R, Lester R
Biochim Biophys Acta
. 2002 Jun;
1583(1):13-25.
PMID: 12069845
Recent advances in understanding sphingolipid metabolism and function in Saccharomyces cerevisiae have moved the field from an embryonic, descriptive phase to one more focused on molecular mechanisms. One advance that...
10.
Skrzypek M, Lester R, Dickson R
Yeast
. 2002 Apr;
19(7):573-86.
PMID: 11967828
Sphingolipid long chain bases (LCBs) in Saccharomyces cerevisiae, dihydrosphingosine (DHS) and phytosphingosine (PHS) and their phosphates (DHS-P and PHS-P) are thought to play roles in heat stress. However, quantitative studies...