Robert Kuchta
Overview
Explore the profile of Robert Kuchta including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
131
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Recent Articles
1.
Bricelj A, Ng Y, Gobec M, Kuchta R, Hu W, Javornik S, et al.
Chemistry
. 2024 May;
30(45):e202400430.
PMID: 38818652
BCL-2, a member of the BCL-2 protein family, is an antiapoptotic factor that regulates the intrinsic pathway of apoptosis. Due to its aberrant activity, it is frequently implicated in haematopoietic...
2.
Kuchta R, Heim C, Herrmann A, Maiwald S, Ng Y, Sosic I, et al.
RSC Chem Biol
. 2023 Mar;
4(3):229-234.
PMID: 36908700
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable...
3.
Bricelj A, Ng Y, Ferber D, Kuchta R, Muller S, Monschke M, et al.
ACS Med Chem Lett
. 2021 Nov;
12(11):1733-1738.
PMID: 34795861
Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands...
4.
Bricelj A, Steinebach C, Kuchta R, Gutschow M, Sosic I
Front Chem
. 2021 Jul;
9:707317.
PMID: 34291038
Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery. These bifunctional molecules consist of a target...
5.
Romaszko J, Cymes I, Draganska E, Kuchta R, Glinska-Lewczuk K
PLoS One
. 2017 Dec;
12(12):e0189938.
PMID: 29267330
Background: The homeless constitute a subpopulation particularly exposed to atmospheric conditions, which, in the temperate climate zone, can result in both cold and heat stress leading to the increased mortality...
6.
Romaszko J, Kuchta R, Opalach C, Bertrand-Bucinska A, Romaszko A, Giergielewicz-Januszko B, et al.
Cent Eur J Public Health
. 2017 Apr;
25(1):29-34.
PMID: 28399352
Background: Homelessness is a form of social pathology, which is for various reasons undesirable and as far as possible limited by efforts such as programmes that assist in transitioning out...
7.
Opalach C, Romaszko J, Jaracz M, Kuchta R, Borkowska A, Bucinski A
PLoS One
. 2016 Sep;
11(9):e0162381.
PMID: 27598582
Background And Objectives: The ways in which homeless individuals cope with stress may differ from those relied upon by the members of the general population and these differences may either...
8.
Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, et al.
J Biol Chem
. 2010 Oct;
285(49):38730-9.
PMID: 20884615
Mps1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in response to spindle damage. The levels of Mps1 are relatively low in cells during interphase...