Robert Kofler
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Explore the profile of Robert Kofler including associated specialties, affiliations and a list of published articles.
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2632
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Recent Articles
1.
Wierzbicki F, Pianezza R, Selvaraju D, Eller M, Kofler R
Mob DNA
. 2025 Feb;
16(1):7.
PMID: 40011995
The horizontal transfer (HT) of the P-element is one of the best documented cases of the HT of a transposable element. The P-element invaded natural D. melanogaster populations between 1950...
2.
Scarpa A, Pianezza R, Gellert H, Haider A, Kim B, Lai E, et al.
Nat Commun
. 2025 Jan;
16(1):516.
PMID: 39788974
Horizontal transfer of genetic material in eukaryotes has rarely been documented over short evolutionary timescales. Here, we show that two retrotransposons, Shellder and Spoink, invaded the genomes of multiple species...
3.
Pianezza R, Haider A, Kofler R
Genome Biol
. 2024 Dec;
25(1):315.
PMID: 39696539
We present GenomeDelta, a novel tool for identifying sample-specific sequences, such as recent transposable element (TE) invasions, without requiring a repeat library. GenomeDelta compares high-quality assemblies with short-read data to...
4.
Pritam S, Scarpa A, Kofler R, Signor S
bioRxiv
. 2024 Oct;
PMID: 39464153
In our current understanding of transposable element (TE) invasions TEs move freely until they accidentally insert into a piRNA cluster. They are then silenced by the production of piRNA cognate...
5.
Scarpa A, Pianezza R, Wierzbicki F, Kofler R
Proc Natl Acad Sci U S A
. 2024 Apr;
121(15):e2313866121.
PMID: 38564639
Transposable element invasions have a profound impact on the evolution of genomes and phenotypes. It is thus an important open question how often such TE invasions occur. To address this...
6.
Pianezza R, Scarpa A, Narayanan P, Signor S, Kofler R
PLoS Genet
. 2024 Mar;
20(3):e1011201.
PMID: 38530818
During the last few centuries D. melanogaster populations were invaded by several transposable elements, the most recent of which was thought to be the P-element between 1950 and 1980. Here...
7.
Selvaraju D, Wierzbicki F, Kofler R
Genome Res
. 2024 Mar;
34(3):410-425.
PMID: 38490738
To prevent the spread of transposable elements (TEs), hosts have developed sophisticated defense mechanisms. In mammals and invertebrates, a major defense mechanism operates through PIWI-interacting RNAs (piRNAs). To investigate the...
8.
Wierzbicki F, Kofler R
BMC Biol
. 2023 Oct;
21(1):224.
PMID: 37858221
Background: It is widely assumed that the invasion of a transposable element (TE) in mammals and invertebrates is stopped when a copy of the TE jumps into a piRNA cluster...
9.
Scarpa A, Kofler R
Genetics
. 2023 Oct;
225(4).
PMID: 37819004
According to the prevailing view, the trap model, the activity of invading transposable elements (TEs) is greatly reduced when a TE copy jumps into a piRNA cluster, which triggers the...
10.
Signor S, Vedanayagam J, Kim B, Wierzbicki F, Kofler R, Lai E
PLoS Genet
. 2023 Aug;
19(8):e1010914.
PMID: 37643184
Suppression of transposable elements (TEs) is paramount to maintain genomic integrity and organismal fitness. In D. melanogaster, the flamenco locus is a master suppressor of TEs, preventing the mobilization of...