Robert K Slany
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Explore the profile of Robert K Slany including associated specialties, affiliations and a list of published articles.
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37
Citations
1753
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Recent Articles
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2.
Garcia-Cuellar M, Akan S, Slany R
Leukemia
. 2023 Aug;
37(9):1850-1859.
PMID: 37532789
The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long (p42) and short (p30) isoform. Mutations within the CEBPA gene...
3.
Garcia-Cuellar M, Prinz A, Slany R
Haematologica
. 2022 May;
107(11):2601-2616.
PMID: 35546301
The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology of acute myeloid leukemia. While HoxA9 alone immortalizes cells, cooperation with Meis1 is necessary to induce a...
4.
Wesolowski R, Kowenz-Leutz E, Zimmermann K, Dorr D, Hofstatter M, Slany R, et al.
Life Sci Alliance
. 2020 Nov;
4(1).
PMID: 33144337
Chromosomal rearrangements of the mixed-lineage leukemia gene are the hallmark of infant acute leukemia. The granulocyte-macrophage progenitor state forms the epigenetic basis for myelomonocytic leukemia stemness and transformation by MLL-type...
5.
Garcia-Cuellar M, Lawlor J, Bottcher M, Mougiakakos D, Metzler M, Slany R
Blood Adv
. 2020 Aug;
4(15):3626-3638.
PMID: 32766858
Mixed-lineage leukemia (MLL) fusions are transcriptional activators that induce leukemia, with a dismal prognosis that mandates further elucidation of their transformation mechanism. In this study, knockdown of the direct MLL-ENL...
6.
Slany R
Biochim Biophys Acta Gene Regul Mech
. 2020 Feb;
1863(3):194503.
PMID: 32061883
The highly leukemogenic MLL fusion proteins have a unique mechanism of action. This review summarizes the current knowledge of how MLL fusions interact with the transcriptional machinery and it proposes...
7.
Sharma A, Jyotsana N, Gabdoulline R, Heckl D, Kuchenbauer F, Slany R, et al.
Haematologica
. 2019 Aug;
105(5):1294-1305.
PMID: 31413090
Mixed lineage leukemia () rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9...
8.
Zhong X, Prinz A, Steger J, Garcia-Cuellar M, Radsak M, Bentaher A, et al.
Blood Adv
. 2018 Nov;
2(22):3137-3148.
PMID: 30463913
Ectopic expression of the oncogenic transcription factor HoxA9 is a major cause of acute myeloid leukemia (AML). Here, we demonstrate that HoxA9 is a specific substrate of granule proteases. Protease...
9.
Hetzner K, Garcia-Cuellar M, Buttner C, Slany R
Blood
. 2017 Dec;
131(6):662-673.
PMID: 29217648
Eleven-nineteen leukemia (ENL) is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense mutations have been identified in Wilms...
10.
Garcia-Cuellar M, Buttner C, Bartenhagen C, Dugas M, Slany R
Cell Rep
. 2016 Apr;
15(2):310-22.
PMID: 27050521
MLL fusions are leukemogenic transcription factors that enhance transcriptional elongation through modification of chromatin and RNA Pol II. Global transcription rates and chromatin changes accompanying the transformation process induced by...