Robert J Pantazes
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Explore the profile of Robert J Pantazes including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
197
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0
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Recent Articles
1.
Recktenwald M, Bhattacharya R, Benmassaoud M, MacAulay J, Chauhan V, Davis L, et al.
ACS Synth Biol
. 2024 Dec;
PMID: 39705005
Transmembrane receptors that endow mammalian cells with the ability to sense and respond to biomaterial-bound ligands will prove instrumental in bridging the fields of synthetic biology and biomaterials. Materials formed...
2.
Islam S, Chauhan V, Pantazes R
MAbs
. 2024 Dec;
17(1):2440586.
PMID: 39690439
Antibody repurposing is the process of changing a known antibody so that it binds to a mutated antigen. One of the findings to emerge from the Coronavirus Disease 2019 (COVID-19)...
3.
Richard A, Pantazes R
Proteins
. 2024 Nov;
93(4):812-830.
PMID: 39601343
The last few years have seen the rapid proliferation of machine learning methods to design binding proteins. Although these methods have shown large increases in experimental success rates compared to...
4.
Austin K, Torres J, Waters J, Balog E, Halpern J, Pantazes R
ACS Omega
. 2024 Sep;
9(37):39219-39231.
PMID: 39310205
Developing a continuous insulin-monitoring biosensor is of great importance for both the cellular biomanufacturing industry and for treating diabetes mellitus. Such a sensor needs to be able to effectively monitor...
5.
Chauhan V, Pantazes R
Protein Eng Des Sel
. 2023 Oct;
36.
PMID: 37889566
After approximately 60 years of work, the protein folding problem has recently seen rapid advancement thanks to the inventions of AlphaFold and RoseTTAFold, which are machine-learning algorithms capable of reliably...
6.
Islam S, Pantazes R
PLoS One
. 2023 Oct;
18(10):e0293606.
PMID: 37883504
The inventions of AlphaFold and RoseTTAFold are revolutionizing computational protein science due to their abilities to reliably predict protein structures. Their unprecedented successes are due to the parallel consideration of...
7.
Chauhan V, Pantazes R
Front Mol Biosci
. 2022 Sep;
9:933400.
PMID: 36106019
Despite the successes of antibodies as therapeutic binding proteins, they still face production and design challenges. Alternative binding scaffolds of smaller size have been developed to overcome these issues. A...
8.
Kamath K, Reifert J, Johnston T, Gable C, Pantazes R, Rivera H, et al.
Sci Rep
. 2020 Mar;
10(1):5294.
PMID: 32210339
The detection of pathogen-specific antibodies remains a cornerstone of clinical diagnostics. Yet, many test exhibit undesirable performance or are completely lacking. Given this, we developed serum epitope repertoire analysis (SERA),...
9.
Entzminger K, Hyun J, Pantazes R, Patterson-Orazem A, Qerqez A, Frye Z, et al.
Sci Rep
. 2017 Sep;
7(1):10295.
PMID: 28860479
Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as...
10.
Pantazes R, Reifert J, Bozekowski J, Ibsen K, Murray J, Daugherty P
Sci Rep
. 2016 Aug;
6:30312.
PMID: 27481573
Disease-specific antibodies can serve as highly effective biomarkers but have been identified for only a relatively small number of autoimmune diseases. A method was developed to identify disease-specific binding motifs...