Robert J Kays
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Explore the profile of Robert J Kays including associated specialties, affiliations and a list of published articles.
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6
Citations
372
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Recent Articles
1.
Tollner T, Venners S, Hollox E, Yudin A, Liu X, Tang G, et al.
Sci Transl Med
. 2011 Jul;
3(92):92ra65.
PMID: 21775668
A glycosylated polypeptide, β-defensin 126 (DEFB126), derived from the epididymis and adsorbed onto the sperm surface, has been implicated in immunoprotection and efficient movement of sperm in mucosal fluids of...
2.
Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract
Karlsson J, Putsep K, Chu H, Kays R, Bevins C, Andersson M
BMC Immunol
. 2008 Jul;
9:37.
PMID: 18637162
Background: Enteric antimicrobial peptides secreted from Paneth cells, including alpha-defensins (in mice named cryptdins), are key effector molecules of innate immunity in the small intestine. The importance of Paneth cells...
3.
George M, Wehkamp J, Kays R, Leutenegger C, Sabir S, Grishina I, et al.
BMC Genomics
. 2008 May;
9:209.
PMID: 18457593
Background: The small intestinal epithelium mediates vital functions of nutrient absorption and host defense. The spatial organization of the epithelial cells along the crypt-villus axis segregates them into regions of...
4.
Hornsby M, Huff J, Kays R, Canfield D, Bevins C, Solnick J
Gastroenterology
. 2008 Apr;
134(4):1049-57.
PMID: 18395086
Background & Aims: We used the rhesus macaque model to study the effects of the cag pathogenicity island (cag PAI) on the H pylori host-pathogen interaction. Methods: H pylori-specific pathogen-free...
5.
Wehkamp J, Wang G, Kubler I, Nuding S, Gregorieff A, Schnabel A, et al.
J Immunol
. 2007 Aug;
179(5):3109-18.
PMID: 17709525
Ileal Crohn's disease (CD), a chronic mucosal inflammation, is characterized by two pertinent features: a specific decrease of Paneth cell-produced antimicrobial alpha-defensins and the presence of mucosal-adherent bacteria. A mutation...
6.
Wehkamp J, Chu H, Shen B, Feathers R, Kays R, Lee S, et al.
FEBS Lett
. 2006 Sep;
580(22):5344-50.
PMID: 16989824
Antimicrobial peptides and proteins are key effectors of innate immunity, expressed both by circulating phagocytic cells and by epithelial cells of mucosal tissues. In the human small intestine, Paneth cells...