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Robert J Halter

Explore the profile of Robert J Halter including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 218
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Peter Wipf
Garth Powis
Lynn Kirkpatrick
Nathan T Ihle
Jonathan A Hodges
Robert Abraham
Margareta I Berggren
Daniel J Minion
Nathan P Bowling
Robert J McMahon
Published In
Org Biomol Chem
Mol Cancer Ther
Org Lett
J Org Chem
J Am Chem Soc
Affiliations
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Recent Articles
1.
Synthesis of simple diynals, diynones, their hydrazones, and diazo compounds: precursors to a family of dialkynyl carbenes (R(1)-C≡C-C-C≡C-R(2))
Bowling N, Burrmann N, Halter R, Hodges J, McMahon R
J Org Chem . 2010 Sep; 75(19):6382-90. PMID: 20812705
A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R(1)-C≡C-C-C≡C-R(2)). In light of the marginal stability associated with these simple systems,...
2.
Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
Ihle N, Lemos R, Schwartz D, Oh J, Halter R, Wipf P, et al.
Mol Cancer Ther . 2009 Jan; 8(1):94-100. PMID: 19139117
The phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascade is an important component of the insulin signaling in normal tissues leading to glucose uptake and homeostasis and for cell survival signaling in cancer...
3.
Synthesis of (+/-)-thiohalenaquinone by iterative metalations of thiophene
Wakefield B, Halter R, Wipf P
Org Lett . 2007 Jul; 9(16):3121-4. PMID: 17630756
The synthesis of a thiophene-containing analogue of halenaquinone was realized. Key steps include an alkynyl ketone-benzocyclobutane Diels-Alder reaction to construct the C,D-ring naphthalene subunit, a Heck cyclization to form the...
4.
Reactive carbon-chain molecules: synthesis of 1-diazo-2,4-pentadiyne and spectroscopic characterization of triplet pentadiynylidene (H-C[triple bond]C-:C-C[triple bond]C-H)
Bowling N, Halter R, Hodges J, Seburg R, Thomas P, Simmons C, et al.
J Am Chem Soc . 2006 Mar; 128(10):3291-302. PMID: 16522111
1-Diazo-2,4-pentadiyne (6a), along with both monodeuterio isotopomers 6b and 6c, has been synthesized via a route that proceeds through diacetylene, 2,4-pentadiynal, and 2,4-pentadiynal tosylhydrazone. Photolysis of diazo compounds 6a-c (lambda...
5.
Chemistry and biology of wortmannin
Wipf P, Halter R
Org Biomol Chem . 2005 May; 3(11):2053-61. PMID: 15917886
Recent synthetic and biological studies of the viridin class of steroidal furans have revealed multiple opportunities for fundamental discoveries as well as advanced drug design. Wortmannin is a potent enzyme...
6.
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
Ihle N, Williams R, Chow S, Chew W, Berggren M, Paine-Murrieta G, et al.
Mol Cancer Ther . 2004 Jul; 3(7):763-72. PMID: 15252137
We have developed biologically stable semisynthetic viridins as inhibitors of phosphoinositide (PtdIns)-3-kinases. The most active compound was PX-866 (acetic acid (1S,4E,10R,11R,13S,14R)-[4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester), which inhibited purified PtdIns-3-kinase with an IC50 of...
7.
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin
Wipf P, Minion D, Halter R, Berggren M, Ho C, Chiang G, et al.
Org Biomol Chem . 2004 Jul; 2(13):1911-20. PMID: 15227545
A series of viridin analogs was prepared from wortmannin by nucleophilic ring opening at C(20) and evaluated against the signaling kinases PI-3-kinase and mTOR. Several subnanomolar enzyme inhibitors with orders...