Robert J Gropler
Overview
Explore the profile of Robert J Gropler including associated specialties, affiliations and a list of published articles.
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196
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3972
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Recent Articles
1.
Vergallo R, Park S, Stone G, Erlinge D, Porto I, Waksman R, et al.
JACC Cardiovasc Imaging
. 2025 Feb;
PMID: 40019413
The concept of high-risk plaque emerged from pathologic and epidemiologic studies 3 decades ago that demonstrated plaque rupture with thrombosis as the predominant mechanism of acute coronary syndrome and sudden...
2.
Gu J, Zheng M, Holden D, Fowles K, Qiu L, Felchner Z, et al.
Mol Imaging Biol
. 2025 Jan;
27(1):54-63.
PMID: 39779653
Purpose: The sphingosine-1-phosphate receptor-1 (S1PR) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers....
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Lavine K, Sultan D, Luehmann H, Detering L, Zhang X, Heo G, et al.
Nat Cardiovasc Res
. 2024 Jul;
2(10):874-880.
PMID: 38947883
Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor 2 (CCR2) is specifically expressed on inflammatory populations of monocytes and macrophages...
7.
Qiu L, Jiang H, Zhou C, Tangadanchu V, Wang J, Huang T, et al.
Org Biomol Chem
. 2024 Jun;
22(26):5428-5453.
PMID: 38884683
Here we report our design and synthesis of 28 new fluorine-containing compounds as potential F-18 radiotracers for CNS imaging of sphingosine-1-phosphate receptor 1 (S1PR1), and determination of their binding potency...
8.
Gu J, Zheng M, Holden D, Fowles K, Qiu L, Felchner Z, et al.
Res Sq
. 2024 Jun;
PMID: 38854065
Purpose: The sphingosine-1-phosphate receptor-1 (S1PR) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers....
9.
Qiu L, Jiang H, Cho K, Yu Y, Jones L, Huang T, et al.
ACS Chem Neurosci
. 2024 Apr;
15(9):1882-1892.
PMID: 38634759
The sphingosine-1-phosphate receptor 1 (S1PR1) radiotracer [C] has shown promise in proof-of-concept PET imaging of neuroinflammation in multiple sclerosis (MS). Our HPLC radiometabolite analysis of human plasma samples collected during...
10.
Zhang X, Heo G, Li A, Lahad D, Detering L, Tao J, et al.
J Nucl Med
. 2024 Mar;
65(5):775-780.
PMID: 38548349
Tissue-resident macrophages are complementary to proinflammatory macrophages to promote the progression of atherosclerosis. The noninvasive detection of their presence and dynamic variation will be important to the understanding of their...