Robert H Wiltrout
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Explore the profile of Robert H Wiltrout including associated specialties, affiliations and a list of published articles.
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2064
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Recent Articles
1.
Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon S, et al.
Cancer Cell
. 2017 Jun;
32(1):57-70.e3.
PMID: 28648284
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai...
2.
Zhu G, Yan H, Pang Y, Jian J, Achyut B, Liang X, et al.
Oncotarget
. 2015 Oct;
6(41):43408-19.
PMID: 26485767
Chemokines and chemokine receptors have critical roles in cancer metastasis and have emerged as one of the targeting options in cancer therapy. However, the treatment efficacy on both tumor and...
3.
Sckisel G, Bouchlaka M, Monjazeb A, Crittenden M, Curti B, Wilkins D, et al.
Immunity
. 2015 Aug;
43(2):240-50.
PMID: 26231116
Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) costimulation, and (3) cytokine-mediated differentiation and expansion. Strong immunostimulatory events such as...
4.
Scarzello A, Jiang Q, Back T, Dang H, Hodge D, Hanson C, et al.
Gut
. 2015 Jul;
65(10):1765-75.
PMID: 26206664
Objectives: The relative contributions of inflammatory signalling and sequential oncogenic dysregulation driving liver cancer pathogenesis remain incompletely understood. Lymphotoxin-β receptor (LTβR) signalling is critically involved in hepatitis and liver tumorigenesis....
5.
Subleski J, Scarzello A, Alvord W, Jiang Q, Stauffer J, Kronfli A, et al.
J Hepatol
. 2015 Jul;
63(5):1181-9.
PMID: 26143441
Background & Aims: Liver inflammatory diseases associated with cancer promoting somatic oncogene mutations are increasing in frequency. Preclinical cancer models that allow for the study of early tumor progression are...
6.
Ridnour L, Cheng R, Weiss J, Kaur S, Soto-Pantoja D, Basudhar D, et al.
Cancer Res
. 2015 May;
75(14):2788-99.
PMID: 25990221
Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated wound healing. Ionizing radiation (IR) is also an immune...
7.
Kapanadze T, Medina-Echeverz J, Gamrekelashvili J, Weiss J, Wiltrout R, Kapoor V, et al.
Eur J Immunol
. 2015 Jan;
45(4):1148-58.
PMID: 25616156
Immunosuppressive CD11b(+) Gr-1(+) myeloid-derived suppressor cells (MDSCs) accumulate in the livers of tumor-bearing (TB) mice. We studied hepatic MDSCs in two murine models of immune-mediated hepatitis. Unexpectedly, treatment of TB...
8.
Mirsoian A, Bouchlaka M, Sckisel G, Chen M, Pai C, Maverakis E, et al.
J Exp Med
. 2014 Nov;
211(12):2373-83.
PMID: 25366964
Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine...
9.
Monjazeb A, Tietze J, Grossenbacher S, Hsiao H, Zamora A, Mirsoian A, et al.
PLoS One
. 2014 Aug;
9(8):e102709.
PMID: 25119341
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells displaying a...
10.
Ortaldo J, Wiltrout R, Reynolds C
Crit Rev Oncog
. 2014 Jun;
19(1-2):1-13.
PMID: 24941370
This manuscript describes the early history of NK cell discovery, with emphasis on the events in the first decade of NK cell studies, 1972-1982. The authors highlight some of the...