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Robert H Miller

Explore the profile of Robert H Miller including associated specialties, affiliations and a list of published articles. Areas
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Articles 166
Citations 5753
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Recent Articles
1.
Schenck J, Clarkson-Paredes C, Pushkarsky T, Wang Y, Miller R, Bukrinsky M
Life Sci Alliance . 2024 Nov; 8(2). PMID: 39532531
The introduction of antiretroviral therapy has markedly improved the management of HIV-associated neurocognitive disorders (HAND). However, HAND still affects nearly half of HIV-infected individuals, presenting significant challenges to their well-being....
2.
Schenck J, Karl M, Clarkson-Paredes C, Bastin A, Pushkarsky T, Brichacek B, et al.
J Neuroinflammation . 2024 May; 21(1):127. PMID: 38741181
HIV-associated neurocognitive disorders (HAND) are a spectrum of cognitive impairments that continue to affect approximately half of all HIV-positive individuals despite effective viral suppression through antiretroviral therapy (ART). White matter...
3.
Clayton B, Kristell J, Allan K, Cohn E, Karl M, Jerome A, et al.
Nat Neurosci . 2024 Feb; 27(4):656-665. PMID: 38378993
Disease, injury and aging induce pathological reactive astrocyte states that contribute to neurodegeneration. Modulating reactive astrocytes therefore represent an attractive therapeutic strategy. Here we describe the development of an astrocyte...
4.
Ahn J, Miller R, Islam Y
J Vis Exp . 2023 Nov; (200). PMID: 37930016
Astrocytes and microglia play pivotal roles in central nervous system development, injury responses, and neurodegenerative diseases. These highly dynamic cells exhibit rapid responses to environmental changes and display significant heterogeneity...
5.
Clarkson-Paredes C, Karl M, Popratiloff A, Miller R
PNAS Nexus . 2023 Oct; 2(10):pgad334. PMID: 37901440
Insults to the central nervous system (CNS) elicit common glial responses including microglial activation evidenced by functional, morphological, and phenotypic changes, as well as astrocyte reactions including hypertrophy, altered process...
6.
Ahn J, Islam Y, Clarkson-Paredes C, Karl M, Miller R
Neurobiol Dis . 2023 Sep; 187:106290. PMID: 37709209
Multiple sclerosis (MS) is characterized by a compromised blood-brain barrier (BBB) resulting in central nervous system (CNS) entry of peripheral lymphocytes, including T cells and B cells. While T cells...
7.
Balraj A, Clarkson-Paredes C, Miller R
Exp Eye Res . 2023 Jun; 233:109540. PMID: 37364629
The myelin sheath facilitates signal conduction along axons in white matter tracts, and when disrupted, can result in significant functional deficits. Demyelination, observed in diseases like multiple sclerosis and optic...
8.
Titus H, Xu H, Robinson A, Patel P, Chen Y, Fantini D, et al.
Glia . 2022 Jul; 70(10):1950-1970. PMID: 35809238
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and...
9.
Ahn J, Islam Y, Miller R
J Neurosci Methods . 2022 Apr; 375:109599. PMID: 35460698
Background: Astrocytes and microglia are essential cellular elements of the CNS that are critical for normal development, function, and injury responses. Both cell types are highly pleiotropic and respond rapidly...
10.
Balraj A, Clarkson-Paredes C, Pajoohesh-Ganji A, Kay M, Mendelowitz D, Miller R
Dev Neurobiol . 2022 Apr; 82(4):308-325. PMID: 35403346
Retinal ganglion cells generate a pattern of action potentials to communicate visual information from the retina to cortical areas. Myelin, an insulating sheath, wraps axonal segments to facilitate signal propagation...