Robert H Dowen
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Explore the profile of Robert H Dowen including associated specialties, affiliations and a list of published articles.
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21
Citations
3173
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Recent Articles
1.
VanDerMolen K, Newman M, Breen P, Gao Y, Huff L, Dowen R
Cell Rep
. 2025 Jan;
44(1):115191.
PMID: 39786994
Organisms allocate energetic resources between essential cellular processes to maintain homeostasis and, in turn, maximize fitness. The nutritional regulators of energy homeostasis have been studied in detail; however, how developmental...
2.
Cully D, Cohen N, Breen P, Newman M, Dowen R
MicroPubl Biol
. 2024 Oct;
2024.
PMID: 39410967
The serine/threonine protein kinase SGK-1 is a downstream target of mTOR complex 2 (mTORC2) and is a conserved regulator of growth and metabolism. In , mutations in , which encodes...
3.
Breen P, Kanakanui K, Newman M, Dowen R
Front Cell Dev Biol
. 2024 Jul;
12:1389077.
PMID: 38946799
The molecular mechanisms that govern the metabolic commitment to reproduction, which often occurs at the expense of somatic reserves, remain poorly understood. We identified the F-box protein FBXL-5 as a...
4.
VanDerMolen K, Newman M, Breen P, Huff L, Dowen R
bioRxiv
. 2024 May;
PMID: 38766075
Organisms must appropriately allocate energetic resources between essential cellular processes to maintain homeostasis and in turn, maximize fitness. The nutritional and homeostatic regulators of energy homeostasis have been studied in...
5.
Torzone S, Breen P, Cohen N, Simmons K, Dowen R
bioRxiv
. 2024 May;
PMID: 38766028
Ion channels are necessary for proper water and nutrient absorption in the intestine, which supports cellular metabolism and organismal growth. While a role for Na co-transporters and pumps in intestinal...
6.
Breen P, Kanakanui K, Newman M, Dowen R
bioRxiv
. 2024 May;
PMID: 38712300
The molecular mechanisms that govern the metabolic commitment to reproduction, which often occurs at the expense of somatic reserves, remain poorly understood. We identified the F-box protein FBXL-5 as a...
7.
DuMez-Kornegay R, Baker L, Morris A, DeLoach W, Dowen R
PLoS Genet
. 2024 Mar;
20(3):e1011003.
PMID: 38547054
The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part due to its purported health benefits, which include protection against metabolic diseases; however, these claims have...
8.
Honey K, Torzone S, Dowen R
MicroPubl Biol
. 2023 Dec;
2023.
PMID: 38116473
The genes encoding the mitogen-activated protein kinases DRL-1 and FLR-4 are required for growth and lipid homeostasis in . Interestingly, the mutant, which was previously isolated in a forward genetic...
9.
Torzone S, Park A, Breen P, Cohen N, Dowen R
PLoS Biol
. 2023 Sep;
21(9):e3002320.
PMID: 37773960
Animals integrate developmental and nutritional signals before committing crucial resources to growth and reproduction; however, the pathways that perceive and respond to these inputs remain poorly understood. Here, we demonstrate...
10.
Gurley N, Szymanski R, Dowen R, Butcher T, Ishiyama N, Peifer M
PLoS One
. 2023 Aug;
18(8):e0289224.
PMID: 37535684
One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic...