Robert G Vries
Overview
Explore the profile of Robert G Vries including associated specialties, affiliations and a list of published articles.
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12
Citations
7118
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Recent Articles
1.
Smabers L, Wensink E, Verissimo C, Koedoot E, Pitsa K, Huismans M, et al.
J Exp Clin Cancer Res
. 2024 Feb;
43(1):61.
PMID: 38414064
Background: The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for...
2.
Kruitwagen H, Oosterhoff L, van Wolferen M, Chen C, Assawarachan S, Schneeberger K, et al.
Cells
. 2020 Feb;
9(2).
PMID: 32053895
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation....
3.
Sachs N, Papaspyropoulos A, Zomer-van Ommen D, Heo I, Bottinger L, Klay D, et al.
EMBO J
. 2019 Jan;
38(4).
PMID: 30643021
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from...
4.
Kruitwagen H, Oosterhoff L, Vernooij I, Schrall I, van Wolferen M, Bannink F, et al.
Stem Cell Reports
. 2017 Mar;
8(4):822-830.
PMID: 28344000
Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause...
5.
Carr D, Ayehunie S, Davies A, Duckworth C, French S, Hall N, et al.
Pharmacol Ther
. 2017 Jan;
172:181-194.
PMID: 28132905
Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts...
6.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, et al.
Nature
. 2016 Oct;
538(7624):260-264.
PMID: 27698416
The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with various age-related diseases, including cancer. Extreme variation in cancer risk across tissues was...
7.
Weeber F, van de Wetering M, Hoogstraat M, Dijkstra K, Krijgsman O, Kuilman T, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(43):13308-11.
PMID: 26460009
Tumor organoids are 3D cultures of cancer cells. They can be derived from the tumor of each individual patient, thereby providing an attractive ex vivo assay to tailor treatment. Using...
8.
Huch M, Dorrell C, Boj S, van Es J, Li V, van de Wetering M, et al.
Nature
. 2013 Jan;
494(7436):247-50.
PMID: 23354049
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional...
9.
Emmink B, van Houdt W, Vries R, Hoogwater F, Govaert K, Verheem A, et al.
Gastroenterology
. 2011 Apr;
141(1):269-78.
PMID: 21459094
Background & Aims: Stem cells of normal tissues have resistance mechanisms that allow them to survive genotoxic insults. The stem cell-like cells of tumors are defined by their tumor-initiating capacity...
10.
Sato T, van Es J, Snippert H, Stange D, Vries R, van den Born M, et al.
Nature
. 2010 Nov;
469(7330):415-8.
PMID: 21113151
Homeostasis of self-renewing small intestinal crypts results from neutral competition between Lgr5 stem cells, which are small cycling cells located at crypt bottoms. Lgr5 stem cells are interspersed between terminally...