Robert G Gourdie
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Explore the profile of Robert G Gourdie including associated specialties, affiliations and a list of published articles.
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121
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3801
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Recent Articles
1.
Wu X, King D, Hoeker G, Wan X, Deschenes I, Johnstone S, et al.
JACC Clin Electrophysiol
. 2025 Mar;
PMID: 40047771
Background: Voltage-gated sodium channel gain of function (NaGOF) is associated with an elevated risk for cardiac arrhythmia. Recent studies have demonstrated that NaGOF can be exacerbated by widening the sodium...
2.
Dogan A, Marsh S, Tschetter R, E Beard C, Amin M, Jourdan L, et al.
J Biol Eng
. 2025 Jan;
19(1):4.
PMID: 39806456
Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. However, maintaining integrity and...
3.
Wu X, Meier L, Liu T, Toldo S, Poelzing S, Gourdie R
Diagnostics (Basel)
. 2024 Oct;
14(20).
PMID: 39451648
Background/objectives: The precise quantification of myocardial infarction is crucial for evaluating therapeutic strategies. We developed a robust, color-based semi-automatic algorithm capable of infarct region detection, isolation and quantification with four...
4.
Bannon M, Ellena J, Gourishankar A, Marsh S, Trevisan-Silva D, Sherman N, et al.
Mol Syst Des Eng
. 2024 Sep;
9(12):1215-1227.
PMID: 39281343
Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets. To overcome this...
5.
Wu X, Meier L, Liu T, Toldo S, Poelzing S, Gourdie R
bioRxiv
. 2024 Sep;
PMID: 39229206
Precise quantification of myocardial infarction is crucial for evaluating the therapeutic strategies. We developed a robust, color-based semi-automatic algorithm capable of infarct region detection, isolation and quantification with four different...
6.
Williams Z, Alvarez-Laviada A, Hoagland D, Jourdan L, Poelzing S, Gorelik J, et al.
J Mol Cell Cardiol
. 2024 Jun;
194():32-45.
PMID: 38942073
Cardiac arrhythmia treatment is a clinical challenge necessitating safer and more effective therapies. Recent studies have highlighted the role of the perinexus, an intercalated disc nanodomain enriched in voltage-gated sodium...
7.
Williams Z, Payne L, Wu X, Gourdie R
Heart Rhythm
. 2024 Jun;
22(1):181-191.
PMID: 38908461
Voltage-gated sodium channels (VGSCs) are transmembrane protein complexes that are vital to the generation and propagation of action potentials in nerve and muscle fibers. The canonical VGSC is generally conceived...
8.
Laurita K, Piktel J, Irish L, Nassal M, Cheng A, McCauley M, et al.
JACC Clin Electrophysiol
. 2024 May;
10(7 Pt 1):1271-1286.
PMID: 38752959
Background: Ventricular tachycardia (VT)/ventricular fibrillation (VF) rearrest after successful resuscitation is common, and survival is poor. A mechanism of VT/VF, as demonstrated in ex vivo studies, is when repolarization alternans...
9.
Tasdemiroglu Y, Council-Troche M, Chen M, Ledford B, Norris R, Poelzing S, et al.
ACS Pharmacol Transl Sci
. 2024 May;
7(5):1624-1636.
PMID: 38751644
In previous research, a synthetic α-carboxyl terminus 1 (αCT1) peptide derived from connexin 43 (Cx43) and its variant (αCT11) showed beneficial effects in an ischemia-reperfusion (I/R) heart injury model in...
10.
Padget R, Zeitz M, Blair G, Wu X, North M, Tanenbaum M, et al.
Circ Res
. 2024 Feb;
134(7):892-912.
PMID: 38415360
Background: Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic understanding. Myocarditis is a major cause of...