Robert G Fenton
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Explore the profile of Robert G Fenton including associated specialties, affiliations and a list of published articles.
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11
Citations
445
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Recent Articles
1.
Badros A, Goloubeva O, Dalal J, Can I, Thompson J, Rapoport A, et al.
Cancer
. 2007 Jul;
110(5):1042-9.
PMID: 17654660
Background: Bortezomib is active in heavily pretreated multiple myeloma patients; the dose-limiting toxicity is peripheral neuropathy (PN). Methods: The authors retrospectively reviewed the incidence, severity, and risk factors for PN...
2.
Dispenzieri A, Gertz M, Lacy M, Geyer S, Fitch T, Fenton R, et al.
Haematologica
. 2006 Mar;
91(3):390-3.
PMID: 16503551
Flavopiridol downregulates anti-apoptotic regulators including Mcl-1, upregulates p53, globally attenuates transcription through inhibition of P-TEFb, binds to DNA, and inhibits angiogenesis. Eighteen myeloma patients were treated with 1-hour flavopiridol infusions...
3.
Badros A, Goloubeva O, Rapoport A, Ratterree B, Gahres N, Meisenberg B, et al.
J Clin Oncol
. 2005 May;
23(18):4089-99.
PMID: 15867202
Purpose: Bcl-2 regulates the mitochondrial apoptosis pathway that promotes chemotherapy resistance. Bcl-2 antisense oligonucleotide, G3139, targets Bcl-2 mRNA. Patients And Methods: G3139 was administered (3 to 7 mg/kg/d for 7...
4.
Takebe N, Cheng X, Wu S, Bauer K, Goloubeva O, Fenton R, et al.
Clin Cancer Res
. 2004 Dec;
10(24):8301-8.
PMID: 15623606
Purpose: Inosine monophosphate dehydrogenase (IMPDH) inhibitors have been used to induce leukemia blast cell differentiation but have not been tested in multiple myeloma for activity. Currently, available IMPDH inhibitor, mycophenolate...
5.
Kowaltowski A, Fenton R, Fiskum G
Free Radic Biol Med
. 2004 Nov;
37(11):1845-53.
PMID: 15528043
Bcl-2 family proteins protect against a variety of forms of cell death, including acute oxidative stress. Previous studies have shown that overexpression of the antiapoptotic protein Bcl-2 increases cellular redox...
6.
Barille-Nion S, Barlogie B, Bataille R, Bergsagel P, Epstein J, Fenton R, et al.
Hematology Am Soc Hematol Educ Program
. 2003 Nov;
:248-78.
PMID: 14633785
Even during this past year, further advances have been made in understanding the molecular genetics of the disease, the mechanisms involved in the generation of myeloma-associated bone disease and elucidation...
7.
Zhang B, Potyagaylo V, Fenton R
Oncogene
. 2003 Mar;
22(12):1848-59.
PMID: 12660820
Mcl-1 is a critical antiapoptotic survival factor for human multiple myeloma (MM). We examined the importance of IL-6 for Mcl-1 expression in five MM cell lines and in primary MM...
8.
Gojo I, Zhang B, Fenton R
Clin Cancer Res
. 2002 Nov;
8(11):3527-38.
PMID: 12429644
Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation of malignant plasma cells with slow proliferative rate but enhanced survival. MM cells express multiple Bcl-2 family members, including...
9.
Zhang B, Fenton R
J Cell Physiol
. 2002 Sep;
193(1):42-54.
PMID: 12209879
The evolutionarily conserved Ras/Raf/MEK/ERK pathway is thought to be essential for proliferation of eukaryotic cells. The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates...
10.
Zhang B, Gojo I, Fenton R
Blood
. 2002 Mar;
99(6):1885-93.
PMID: 11877256
Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow caused primarily by failure of normal homeostatic mechanisms to prevent the expansion of postgerminal...