Robert E Hynds
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Explore the profile of Robert E Hynds including associated specialties, affiliations and a list of published articles.
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54
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1374
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Recent Articles
1.
Ishii Y, Orr J, El Mdawar M, de Pilger D, Pearce D, Lazarus K, et al.
J Cell Sci
. 2025 Mar;
PMID: 40065746
Regeneration of the airway epithelium restores barrier function and mucociliary clearance following lung injury and infection. The mechanisms regulating the proliferation and differentiation of tissue-resident airway basal stem cells remain...
2.
Greenwood H, Barber A, Edwards R, Tyrrell W, George M, Dos Santos S, et al.
Nat Commun
. 2024 Dec;
15(1):10484.
PMID: 39690148
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. Currently, there is no means to non-invasively identify...
3.
Orr J, Laali A, Durrenberger P, Lazarus K, El Mdawar M, Janes S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Aug;
327(4):L587-L599.
PMID: 39137525
Basal cells are adult stem cells in the airway epithelium and regenerate differentiated cell populations, including the mucosecretory and ciliated cells that enact mucociliary clearance. Human basal cells can proliferate...
4.
Dietzen M, Zhai H, Lucas O, Pich O, Barrington C, Lu W, et al.
Nat Commun
. 2024 Jul;
15(1):6039.
PMID: 39019871
During each cell cycle, the process of DNA replication timing is tightly regulated to ensure the accurate duplication of the genome. The extent and significance of alterations in this process...
5.
Woodall M, Cujba A, Worlock K, Case K, Masonou T, Yoshida M, et al.
Nat Microbiol
. 2024 Jun;
9(11):3076.
PMID: 38890492
No abstract available.
6.
Hobor S, Al Bakir M, Hiley C, Skrzypski M, Frankell A, Bakker B, et al.
Nat Commun
. 2024 Jun;
15(1):4871.
PMID: 38871738
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here,...
7.
Hynds R, Huebner A, Pearce D, Hill M, Akarca A, Moore D, et al.
Nat Commun
. 2024 May;
15(1):4653.
PMID: 38821942
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients...
8.
Hynds R, Magin C, Ikonomou L, Aschner Y, Beers M, Burgess J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(3):L327-L340.
PMID: 38772903
Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past...
9.
Woodall M, Cujba A, Worlock K, Case K, Masonou T, Yoshida M, et al.
Nat Microbiol
. 2024 Apr;
9(5):1293-1311.
PMID: 38622380
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected people over 85 years of age remains high. Here we investigate differences in the...
10.
Lau C, Rouhani M, Maughan E, Orr J, Kolluri K, Pearce D, et al.
Mol Ther
. 2024 Mar;
32(5):1497-1509.
PMID: 38429928
The hallmark of epidermolysis bullosa (EB) is fragile attachment of epithelia due to genetic variants in cell adhesion genes. We describe 16 EB patients treated in the ear, nose, and...