Robert C Wirka
Overview
Explore the profile of Robert C Wirka including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
706
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0
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Recent Articles
1.
Cheng P, Wirka R, Kim J, Kim H, Nguyen T, Kundu R, et al.
Nat Cardiovasc Res
. 2022 Oct;
1(4):322-333.
PMID: 36246779
Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. Allelic variation at 15q22.33 has been identified by...
2.
Pedroza A, Dalal A, Shad R, Yokoyama N, Nakamura K, Cheng P, et al.
Arterioscler Thromb Vasc Biol
. 2022 Jul;
42(9):1154-1168.
PMID: 35861960
Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Disparate responses to disease-causing variants by these lineages are proposed to promote...
3.
Cheng P, Wirka R, Shoa Clarke L, Zhao Q, Kundu R, Nguyen T, et al.
Circulation
. 2022 Jan;
145(6):469-485.
PMID: 34990206
Background: Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the...
4.
5.
Gallina A, Rykaczewska U, Wirka R, Caravaca A, Shavva V, Youness M, et al.
Front Cardiovasc Med
. 2021 May;
8:655869.
PMID: 33959644
Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic...
6.
Nurnberg S, Guerraty M, Wirka R, Rao H, Pjanic M, Norton S, et al.
PLoS Genet
. 2020 Jan;
16(1):e1008538.
PMID: 31917787
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary...
7.
Rykaczewska U, Suur B, Rohl S, Razuvaev A, Lengquist M, Sabater-Lleal M, et al.
Circ Res
. 2020 Jan;
126(5):571-585.
PMID: 31893970
Rationale: PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation,...
8.
Nagao M, Lyu Q, Zhao Q, Wirka R, Bagga J, Nguyen T, et al.
Circ Res
. 2019 Dec;
126(4):517-529.
PMID: 31815603
Rationale: The gene encoding TCF21 (transcription factor 21) has been linked to coronary artery disease risk by human genome-wide association studies in multiple racial ethnic groups. In murine models, Tcf21...
9.
Wirka R, Wagh D, Paik D, Pjanic M, Nguyen T, Miller C, et al.
Nat Med
. 2019 Jul;
25(8):1280-1289.
PMID: 31359001
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo...
10.
Paik D, Tian L, Lee J, Sayed N, Chen I, Rhee S, et al.
Circ Res
. 2018 Jul;
123(4):443-450.
PMID: 29986945
Rationale: Human-induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool in cardiovascular research, offering a wide gamut of translational and clinical applications. However, inefficiency of the...