Robert C Orchard
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Explore the profile of Robert C Orchard including associated specialties, affiliations and a list of published articles.
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38
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1405
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Recent Articles
1.
Song J, Zhang L, Moon S, Fang A, Wang G, Gheshm N, et al.
Sci Adv
. 2025 Feb;
11(9):eadu7985.
PMID: 40020060
Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored. Here, we...
2.
Olson M, Orchard R
bioRxiv
. 2025 Jan;
PMID: 39868277
Caliciviruses are significant agricultural and human pathogens that are poorly understood due to the dearth of molecular tools, including reporter systems. We report the development of a stable, faithful, and...
3.
Zhang J, Orchard R, Kuang Z
Immunometabolism (Cobham)
. 2024 Dec;
6(4):e00052.
PMID: 39634021
Norovirus is a leading cause of gastroenteritis worldwide. The factors required for the life cycle and pathogenesis of norovirus in humans remain unclear. Mouse models of norovirus infection have been...
4.
Stewart B, Pierce L, Olson M, Orchard R
bioRxiv
. 2024 Nov;
PMID: 39574648
Norovirus, the leading cause of gastroenteritis worldwide, is a non-enveloped virus whose tropism is determined in part by the expression patterns of entry receptors. However, the contribution of cellular lipids...
5.
Chang T, Alvarez J, Chappidi S, Crockett S, Sorouri M, Orchard R, et al.
PLoS Pathog
. 2024 Oct;
20(10):e1012673.
PMID: 39475961
Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the upregulation of hundreds of mRNAs termed interferon-stimulated genes...
6.
Srinivas M, Pierce L, Olson M, Roberston S, Sturdevant G, Best S, et al.
bioRxiv
. 2024 Oct;
PMID: 39464121
Trim7 is an E3 ubiquitin ligase that was recently identified as a central regulator of host-viral interactions with both pro-viral and anti-viral activity in cell culture. As an inhibitor, Trim7...
7.
Chang T, Alvarez J, Chappidi S, Crockett S, Sorouri M, Orchard R, et al.
bioRxiv
. 2024 Oct;
PMID: 39416205
Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the upregulation of hundreds of mRNAs termed interferon-stimulated genes...
8.
Zhang J, Wang G, Ma J, Duan Y, Sharma S, Oladejo S, et al.
Sci Immunol
. 2024 Sep;
9(99):eadk7387.
PMID: 39331726
The intestinal mucosal surface is directly exposed to daily fluctuations in food and microbes driven by 24-hour light and feeding cycles. Intestinal epithelial tuft cells are key sentinels that surveil...
9.
Munir M, Embry A, Doench J, Heaton N, Wilen C, Orchard R
J Biol Chem
. 2024 Mar;
300(4):107153.
PMID: 38462163
The innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape, we conducted a gain-of-function, genome-wide CRISPR activation screen...
10.
Munir M, Embry A, Doench J, Heaton N, Wilen C, Orchard R
bioRxiv
. 2023 Oct;
PMID: 37808733
The innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape we conducted a gain of function, genome-wide CRISPR...