Robert C M Knaap
Overview
Explore the profile of Robert C M Knaap including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
345
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
van Huizen M, Bloeme-Ter Horst J, de Gruyter H, Geurink P, van der Heden van Noort G, Knaap R, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012100.
PMID: 38527094
The coronavirus papain-like protease (PLpro) is crucial for viral replicase polyprotein processing. Additionally, PLpro can subvert host defense mechanisms by its deubiquitinating (DUB) and deISGylating activities. To elucidate the role...
2.
Bailey-Elkin B, Knaap R, De Silva A, Boekhoud I, Mous S, van Vught N, et al.
PLoS Pathog
. 2023 Dec;
19(12):e1011872.
PMID: 38096325
Deubiquitination of cellular substrates by viral proteases is a mechanism used to interfere with host cellular signaling processes, shared between members of the coronavirus- and arterivirus families. In the case...
3.
Myeni S, Bredenbeek P, Knaap R, Dalebout T, Morales S, Sidorov I, et al.
Nat Commun
. 2023 Feb;
14(1):1141.
PMID: 36854765
Coronaviruses express a papain-like protease (PLpro) that is required for replicase polyprotein maturation and also serves as a deubiquitinating enzyme (DUB). In this study, using a Middle East respiratory syndrome...
4.
Geurink P, van der Heden van Noort G, Mulder M, Knaap R, Kikkert M, Ovaa H
Methods Enzymol
. 2019 Mar;
618:357-387.
PMID: 30850060
Protein (poly-)ubiquitination is a posttranslational modification that plays a key role in almost all cellular processes. It involves the installment of either single ubiquitin (Ub) moieties or one of eight...
5.
Bailey-Elkin B, Knaap R, Kikkert M, Mark B
J Mol Biol
. 2017 Jun;
429(22):3441-3470.
PMID: 28625850
Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including innate and adaptive immune responses. Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs),...
6.
Zhang W, Bailey-Elkin B, Knaap R, Khare B, Dalebout T, Johnson G, et al.
PLoS Pathog
. 2017 May;
13(5):e1006372.
PMID: 28542609
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective...
7.
Rabouw H, Langereis M, Knaap R, Dalebout T, Canton J, Sola I, et al.
PLoS Pathog
. 2016 Oct;
12(10):e1005982.
PMID: 27783669
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like most other viruses, must navigate through an intricate...
8.
van Kasteren P, Knaap R, van den Elzen P, Snijder E, Balasuriya U, van den Born E, et al.
Vet Microbiol
. 2015 May;
178(1-2):132-7.
PMID: 25975520
Arteriviruses are a family of positive-stranded RNA viruses that includes the prototypic equine arteritis virus (EAV) and porcine reproductive and respiratory syndrome virus (PRRSV). Although several vaccines against these viruses...
9.
Bailey-Elkin B, Knaap R, Johnson G, Dalebout T, Ninaber D, van Kasteren P, et al.
J Biol Chem
. 2014 Oct;
289(50):34667-82.
PMID: 25320088
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-encoded papain-like protease (PL(pro)) that...