Robert C Grant
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Explore the profile of Robert C Grant including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Walker R, Joo J, Mahmood K, Clendenning M, Como J, Preston S, et al.
medRxiv
. 2024 Aug;
PMID: 39148833
Background: Colorectal cancers (CRCs) from people with biallelic germline likely pathogenic/pathogenic variants in or exhibit specific single base substitution (SBS) mutational signatures, namely combined SBS18 and SBS36 (SBS18+SBS36), and SBS30,...
12.
Guan Q, Aktar S, Pataky R, Stephen M, Marques M, Gambaro K, et al.
Curr Oncol
. 2024 Jun;
31(6):3591-3602.
PMID: 38920747
Niraparib was recently funded in Canada for the maintenance treatment of ovarian cancer following platinum-based chemotherapy. However, the drug's safety profile in the real world remains uncertain. We conducted a...
13.
Longwell J, Hirsch I, Binder F, Gonzalez Conchas G, Mau D, Jang R, et al.
JAMA Netw Open
. 2024 Jun;
7(6):e2417641.
PMID: 38888919
Importance: Large language models (LLMs) recently developed an unprecedented ability to answer questions. Studies of LLMs from other fields may not generalize to medical oncology, a high-stakes clinical setting requiring...
14.
Sinicrope F, Nelson G, Saberzadeh-Ardestani B, Segovia D, Graham R, Wu C, et al.
Cancer Res Commun
. 2024 May;
4(5):1344-1350.
PMID: 38709069
Significance: A deep learning algorithm can quantify tumor morphologic features that may reflect underlying mechanisms driving prognosis within MMR groups. TSR was the most robust morphologic feature associated with TTR...
15.
He J, Moffat G, Podolsky S, Khan F, Liu N, Taback N, et al.
J Clin Oncol
. 2024 Feb;
42(14):1625-1634.
PMID: 38359380
Purpose: For patients with advanced cancer, early consultations with palliative care (PC) specialists reduce costs, improve quality of life, and prolong survival. However, capacity limitations prevent all patients from receiving...
16.
Madariaga A, Cole H, Pittman T, Grant R, Dhani N, Liu A, et al.
Gynecol Oncol
. 2024 Feb;
185:1-7.
PMID: 38342004
Objective: The primary objective is to assess factors associated with treatment related high grade (CTCAE grade ≥ 3) adverse event (AE) reporting among participants in gynecologic oncology clinical trials. Methods:...
17.
Cornish N, Haycock P, Brenner H, Figueiredo J, Galesloot T, Grant R, et al.
Int J Epidemiol
. 2023 Dec;
53(1).
PMID: 38124529
Background: People with cancer experience high rates of venous thromboembolism (VTE). Risk of subsequent cancer is also increased in people experiencing their first VTE. The causal mechanisms underlying this association...
18.
Vogel A, Grant R, Meyer T, Sapisochin G, OKane G, Saborowski A
Hepatology
. 2023 Dec;
PMID: 38108634
Immune-oncology-based regimens have shown efficacy in advanced HCC and have been implemented as standard of care as first-line therapy. Their efficacy, including high response rates, and safety justify their evaluation...
19.
Lee C, OKane G, Mason W, Zhang W, Spiliopoulou P, Hansen A, et al.
Mol Cancer Ther
. 2023 Nov;
23(3):394-399.
PMID: 38015561
Isocitrate dehydrogenase (IDH) enzymes catalyze the decarboxylation of isocitrate to alpha-ketoglutarate (αKG). IDH1/2 mutations preferentially convert αKG to R-2-hydroxyglutarate (R2HG), resulting in R2HG accumulation in tumor tissues. We investigated circulating...
20.
Grant R, He J, Khan F, Liu N, Podolsky S, Kaliwal Y, et al.
J Natl Compr Canc Netw
. 2023 Oct;
21(10):1029-1037.e21.
PMID: 37856226
Background: Emergency department visits and hospitalizations frequently occur during systemic therapy for cancer. We developed and evaluated a longitudinal warning system for acute care use. Methods: Using a retrospective population-based...