Robert Bentham
Overview
Explore the profile of Robert Bentham including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
581
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Recent Articles
1.
Bentham R, Jones T, Black J, Martinez-Ruiz C, Dietzen M, Litovchenko M, et al.
Nat Genet
. 2025 Feb;
57(3):694-705.
PMID: 39966644
Recognition and elimination of pathogens and cancer cells depend on the adaptive immune system. Thus, accurate quantification of immune subsets is vital for precision medicine. We present immune lymphocyte estimation...
2.
Bailey C, Pich O, Thol K, Watkins T, Luebeck J, Rowan A, et al.
Nature
. 2024 Nov;
635(8037):193-200.
PMID: 39506150
Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer. Here we examine the diversity of ecDNA elements across cancer, revealing the associated...
3.
Puttick C, Jones T, Leung M, Galvez-Cancino F, Liu J, Varas-Godoy M, et al.
Nat Genet
. 2024 Oct;
56(10):2121-2131.
PMID: 39358601
Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific mutation...
4.
Culliford R, Lawrence S, Mills C, Tippu Z, Chubb D, Cornish A, et al.
Nat Commun
. 2024 Jul;
15(1):5935.
PMID: 39009593
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We report the whole genome sequencing...
5.
Frankell A, Dietzen M, Al Bakir M, Lim E, Karasaki T, Ward S, et al.
Nature
. 2024 Jul;
631(8022):E15.
PMID: 38965439
No abstract available.
6.
Mills C, Sud A, Everall A, Chubb D, Lawrence S, Kinnersley B, et al.
NPJ Precis Oncol
. 2024 May;
8(1):122.
PMID: 38806682
Interval breast cancers (IBCs) are cancers diagnosed between screening episodes. Understanding the biological differences between IBCs and screen-detected breast-cancers (SDBCs) has the potential to improve mammographic screening and patient management....
7.
Houlston R, Culliford R, Lawrence S, Mills C, Tippu Z, Chubb D, et al.
Res Sq
. 2023 Dec;
PMID: 38106039
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We report the whole genome sequencing...
8.
Frankell A, Dietzen M, Al Bakir M, Lim E, Karasaki T, Ward S, et al.
Nature
. 2023 Apr;
616(7957):525-533.
PMID: 37046096
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell...
9.
Bentham R, Litchfield K, Watkins T, Lim E, Rosenthal R, Martinez-Ruiz C, et al.
Nature
. 2021 Sep;
597(7877):555-560.
PMID: 34497419
The immune microenvironment influences tumour evolution and can be both prognostic and predict response to immunotherapy. However, measurements of tumour infiltrating lymphocytes (TILs) are limited by a shortage of appropriate...
10.
Litchfield K, Reading J, Puttick C, Thakkar K, Abbosh C, Bentham R, et al.
Cell
. 2021 Jan;
184(3):596-614.e14.
PMID: 33508232
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization. Here, we collated whole-exome and transcriptomic data for...