Alpha 2.0
Login Register
» Authors » Robert Asaad

Robert Asaad

Explore the profile of Robert Asaad including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 29
Citations 1018
Followers 0
Related Specialties
Infectious Diseases
Allergy & Immunology
Hematology
Top 10 Co-Authors
Michael M Lederman
Benigno Rodriguez
Hernan Valdez
Scott F Sieg
Donald D Anthony
Kathy Medvik
Christoph G Lange
Nicole L Yonkers
Wei Jiang
Nicholas T Funderburg
Published In
AIDS
Clin Immunol
Blood
J Acquir Immune Defic Syndr
J Immunol
Affiliations
Soon will be listed here.
Recent Articles
1.
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
Joussef-Pina S, Nankya I, Nalukwago S, Baseke J, Rwambuya S, Winner D, et al.
Retrovirology . 2022 Jan; 19(1):1. PMID: 35033105
Background: Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with...
2.
Stability of plasma indices of inflammation/coagulation and homeostasis after fatty and non-fatty meals in treated people with HIV
Dorazio D, Kitch D, Utay N, Macatangay B, Landay A, Brown T, et al.
J Virus Erad . 2019 Feb; 5(1):28-32. PMID: 30800423
Objectives: The relationship between lipid levels in plasma and inflammatory indices is complex and fatty meals alter plasma inflammatory markers in people with diabetes. There is interest in monitoring the...
3.
Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals
Weber J, Gibson R, Sacka L, Strunin D, Hodek J, Weberova J, et al.
AIDS Res Ther . 2017 Mar; 14:15. PMID: 28331526
Background: Progression rates from initial HIV-1 infection to advanced AIDS vary significantly among infected individuals. A distinct subgroup of HIV-1-infected individuals-termed viremic non-progressors (VNP) or controllers-do not seem to progress...
4.
Proteome and Protein Network Analyses of Memory T Cells Find Altered Translation and Cell Stress Signaling in Treated Human Immunodeficiency Virus Patients Exhibiting Poor CD4 Recovery
Azzam S, Schlatzer D, Maxwell S, Li X, Bazdar D, Chen Y, et al.
Open Forum Infect Dis . 2017 Mar; 3(2):ofw037. PMID: 28293663
 Human immunodeficiency virus (HIV) patients who experience poor CD4 T-cell recovery despite viral suppression during antiretroviral therapy (ART) are known as immunological nonresponders. The molecular mechanism(s) underlying incomplete immune restoration...
5.
Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor CD4+ T-cell recovery
Nguyen T, Shukla S, Asaad R, Freeman M, Lederman M, Harding C, et al.
AIDS . 2016 May; 30(13):2033-42. PMID: 27191978
Objective: To assess CD4 T-cell responsiveness to IL-7 and IFN-α in HIV-infected patients who experience poor recovery of CD4 T-cell counts during therapy (immune failure patients). Design: Responses to IL-7...
6.
Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
Hardy G, Sieg S, Rodriguez B, Anthony D, Asaad R, Jiang W, et al.
PLoS One . 2013 Feb; 8(2):e56527. PMID: 23437155
Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated...
7.
Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression
Mayne E, Funderburg N, Sieg S, Asaad R, Kalinowska M, Rodriguez B, et al.
J Acquir Immune Defic Syndr . 2011 Dec; 59(4):340-6. PMID: 22156911
Objective: HIV-1-infected patients have an increased risk for atherothrombosis and cardiovascular disease, but the mechanism behind these risks is poorly understood. We have previously reported that expression of tissue factor...
8.
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
Lederman M, Calabrese L, Funderburg N, Clagett B, Medvik K, Bonilla H, et al.
J Infect Dis . 2011 Sep; 204(8):1217-26. PMID: 21917895
Background: Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection. Methods: To evaluate potential determinants of immune failure in...
9.
Systemic immune activation in HIV infection is associated with decreased MDC responsiveness to TLR ligand and inability to activate naive CD4 T-cells
Yonkers N, Rodriguez B, Asaad R, Lederman M, Anthony D
PLoS One . 2011 Sep; 6(9):e23884. PMID: 21912648
Background: HIV infection is characterized by ineffective anti-viral T-cell responses and impaired dendritic cell (DC) functions, including response to Toll-Like Receptor (TLR) ligands. Because TLR responsiveness may affect a host's...
10.
Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease
Rodriguez B, Bazdar D, Funderburg N, Asaad R, Luciano A, Yadavalli G, et al.
J Leukoc Biol . 2011 Jun; 90(3):621-8. PMID: 21653240
HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV...