Rita Bernhardt
Overview
Explore the profile of Rita Bernhardt including associated specialties, affiliations and a list of published articles.
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Articles
191
Citations
2118
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Recent Articles
1.
Petkova-Kirova P, Kolchina A, Baas S, Wagenpfeil G, Unger M, Schulze-Hentrich J, et al.
Front Pharmacol
. 2024 Oct;
15:1477009.
PMID: 39403150
Besides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology...
2.
Petkova-Kirova P, Baas S, Wagenpfeil G, Hartz P, Unger M, Bernhardt R
Front Pharmacol
. 2023 Aug;
14:1244516.
PMID: 37601072
Parkinson's disease (PD) is one of the most frequent neurological diseases affecting millions of people worldwide. While the majority of PD cases are of unknown origin (idiopathic), about 5%-10% are...
3.
Jozwik I, Bombino E, Abdulmughni A, Hartz P, Rozeboom H, Wijma H, et al.
FEBS J
. 2023 Jul;
290(20):5016-5035.
PMID: 37453052
The P450 monooxygenase CYP109A2 from Bacillus megaterium DSM319 was previously found to convert vitamin D3 (VD3) to 25-hydroxyvitamin D3. Here, we show that this enzyme is also able to convert...
4.
Hartz P, Fehlmann T, Wagenpfeil G, Unger M, Bernhardt R
Front Pharmacol
. 2023 Feb;
13:1094265.
PMID: 36744208
Genetic and environmental factors lead to the manifestation of Parkinson's disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds...
5.
Carius Y, Hutter M, Kiss F, Bernhardt R, Lancaster C
FEBS Lett
. 2022 Sep;
596(24):3133-3144.
PMID: 36151590
Understanding the structural basis of the selectivity of steroid hydroxylation requires detailed structural and functional investigations on various steroid hydroxylases with different selectivities, such as the bacterial cytochrome P450 enzymes....
6.
Hartz P, Strohmaier S, El-Gayar B, Abdulmughni A, Hutter M, Hannemann F, et al.
FEBS J
. 2021 Jun;
288(22):6510-6527.
PMID: 34092040
Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s were able to retain their oxygenase function following relocation to...
7.
Putkaradze N, Hartz P, Hutter M, Zapp J, Thevis M, Bernhardt R
J Steroid Biochem Mol Biol
. 2021 Jun;
212:105927.
PMID: 34089835
The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory...
8.
Bernhardt R, Neunzig J
Mol Cell Endocrinol
. 2021 Mar;
530:111237.
PMID: 33722664
Although cytochrome P450 (CYP) systems including the adrenal ones are being investigated since many years, there are still reactions and regulation patterns that have been underestimated ever since. This review...
9.
Hartz P, Gehl M, Konig L, Bernhardt R, Hannemann F
J Biotechnol
. 2021 Feb;
329:170-179.
PMID: 33600891
Bacillus megaterium has become increasingly important for the biotechnological production of valuable compounds of industrial and pharmaceutical importance. Despite recent advances in rational strain design of B. megaterium, these studies...
10.
Abdulmughni A, Erichsen B, Hensel J, Hannemann F, Bernhardt R
J Biotechnol
. 2020 Dec;
325:355-359.
PMID: 33268138
Calcifediol (25(OH)VD3) is a physiologically very important vitamin D metabolite and of high pharmaceutical importance, due to its potential for treating not only vitamin D deficiencies but also coronary diseases...