Rick Xing Ze Lu
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Explore the profile of Rick Xing Ze Lu including associated specialties, affiliations and a list of published articles.
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15
Citations
193
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Recent Articles
1.
Xu Y, Ma S, Cui H, Chen J, Xu S, Gong F, et al.
Nat Commun
. 2024 Jul;
15(1):6305.
PMID: 39060305
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of...
2.
Wu Q, Rafatian N, Wagner K, Blamer J, Smith J, Okhovatian S, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(28):e2403581121.
PMID: 38968108
Adverse cardiac outcomes in COVID-19 patients, particularly those with preexisting cardiac disease, motivate the development of human cell-based organ-on-a-chip models to recapitulate cardiac injury and dysfunction and for screening of...
3.
Landau S, Zhao Y, Hamidzada H, Kent G, Okhovatian S, Lu R, et al.
Cell Stem Cell
. 2024 Jun;
31(8):1222-1238.e10.
PMID: 38908380
The intricate anatomical structure and high cellular density of the myocardium complicate the bioengineering of perfusable vascular networks within cardiac tissues. In vivo neonatal studies highlight the key role of...
4.
Lu R, Zhao Y, Radisic M
Bioeng Transl Med
. 2024 May;
9(3):e10581.
PMID: 38818123
Coronavirus disease 2019 (COVID-19) has been a major global health concern since its emergence in 2019, with over 680 million confirmed cases as of April 2023. While COVID-19 has been...
5.
Lu R, Rafatian N, Zhao Y, Wagner K, Beroncal E, Li B, et al.
Sci Adv
. 2024 Mar;
10(13):eadk0164.
PMID: 38536913
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model...
6.
Chen J, Xu Y, Zhou M, Xu S, Varley A, Golubovic A, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2309472120.
PMID: 38060560
Ionizable lipid nanoparticles (LNPs) pivotal to the success of COVID-19 mRNA (messenger RNA) vaccines hold substantial promise for expanding the landscape of mRNA-based therapies. Nevertheless, the risk of mRNA delivery...
7.
Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Masse S, et al.
Biomaterials
. 2023 Aug;
301:122255.
PMID: 37651922
To better understand sodium channel (SCN5A)-related cardiomyopathies, we generated ventricular cardiomyocytes from induced pluripotent stem cells obtained from a dilated cardiomyopathy patient harbouring the R222Q mutation, which is only expressed...
8.
Lu R, Rafatian N, Zhao Y, Wagner K, Beroncal E, Li B, et al.
bioRxiv
. 2023 Aug;
PMID: 37609237
Cardiovascular disease continues to take more human lives than all cancer combined, prompting the need for improved research models and treatment options. Despite a significant progress in development of mature...
9.
Lu R, Lai B, Rafatian N, Gustafson D, Campbell S, Banerjee A, et al.
Lab Chip
. 2022 Feb;
22(6):1171-1186.
PMID: 35142777
Coronavirus disease 2019 (COVID-19) was primarily identified as a novel disease causing acute respiratory syndrome. However, as the pandemic progressed various cases of secondary organ infection and damage by severe...
10.
Wang E, Kuzmanov U, Smith J, Dou W, Rafatian N, Lai B, et al.
J Mol Cell Cardiol
. 2021 Jul;
160:97-110.
PMID: 34216608
Angiotensin II (Ang II) presents a critical mediator in various pathological conditions such as non-genetic cardiomyopathy. Osmotic pump infusion in rodents is a commonly used approach to model cardiomyopathy associated...