Richard W Orrell
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Explore the profile of Richard W Orrell including associated specialties, affiliations and a list of published articles.
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62
Citations
5469
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Recent Articles
1.
Gould R, McDermott C, Thompson B, Rawlinson C, Bursnall M, Bradburn M, et al.
Lancet
. 2024 May;
403(10442):2381-2394.
PMID: 38735299
Background: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour...
2.
Young C, Chaouch A, McDermott C, Al-Chalabi A, Chhetri S, Talbot K, et al.
Amyotroph Lateral Scler Frontotemporal Degener
. 2024 Mar;
25(5-6):475-485.
PMID: 38465877
Objective: Dyspnea, or breathlessness, is an important symptom in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND). We examined the measurement properties of the Dyspnea-12. Methods: Rasch analysis enabled conversion of raw...
3.
Fisher E, Greensmith L, Malaspina A, Fratta P, Hanna M, Schiavo G, et al.
Mol Neurodegener
. 2023 May;
18(1):30.
PMID: 37143081
Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic' of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30...
4.
van Rheenen W, van der Spek R, Bakker M, van Vugt J, Hop P, Zwamborn R, et al.
Nat Genet
. 2022 Feb;
54(3):361.
PMID: 35102318
No abstract available.
5.
van Rheenen W, van der Spek R, Bakker M, van Vugt J, Hop P, Zwamborn R, et al.
Nat Genet
. 2021 Dec;
53(12):1636-1648.
PMID: 34873335
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide...
6.
Johnson J, Miller D, Li R, Kumaran R, Alahmady N, Cookson M, et al.
JAMA Neurol
. 2021 Aug;
78(10):1236-1248.
PMID: 34459874
Importance: Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation. Objective: To identify the...
7.
Nicolas A, Kenna K, Renton A, Ticozzi N, Faghri F, Chia R, et al.
Neuron
. 2018 Mar;
97(6):1267-1288.
PMID: 29566793
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed...
8.
Orrell R
Practitioner
. 2017 Nov;
260(1796):17-21.
PMID: 29116729
Motor neurone disease is a rapidly progressive and fatal neurodegenerative condition which causes progressive weakness, with normal sensation. It can occur at any age but is more frequent with increasing...
9.
Morgan S, Shatunov A, Sproviero W, Jones A, Shoai M, Hughes D, et al.
Brain
. 2017 Apr;
140(6):1611-1618.
PMID: 28430856
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of motor neurons. About 25 genes have been verified as relevant to the disease process, with rare and common variation implicated. We...
10.
McGeachan A, Hobson E, Al-Chalabi A, Stephenson J, Chandran S, Crawley F, et al.
Amyotroph Lateral Scler Frontotemporal Degener
. 2016 Sep;
18(1-2):1-9.
PMID: 27579520
Failure to clear oral secretions can be debilitating for patients with amyotrophic lateral sclerosis (ALS), but the treatment of this symptom is poorly defined and there is no consensus on...