Richard Swanson
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Explore the profile of Richard Swanson including associated specialties, affiliations and a list of published articles.
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32
Citations
562
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Recent Articles
1.
Huang X, Swanson R, Wang C, Du X
Arterioscler Thromb Vasc Biol
. 2025 Feb;
PMID: 39973748
Background: The protein ZPI (Z-dependent protease inhibitor) binds to PZ (protein Z), which enables ZPI to inhibit membrane-bound FXa (activated factor X). ZPI also inhibits FXIa (activated factor XI) independently...
2.
Sussman T, Severgnini M, Giobbie-Hurder A, Friedlander P, Swanson S, Jaklitsch M, et al.
Front Oncol
. 2024 May;
14:1395978.
PMID: 38812776
Background: In the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements. Prior studies have demonstrated delayed type hypersensitivity...
3.
Huang X, Swanson R, Olson S
J Biol Chem
. 2022 May;
298(6):102022.
PMID: 35551912
Protein Z (PZ)-dependent protease inhibitor (ZPI) is a plasma anticoagulant protein of the serpin superfamily, which is activated by its cofactor, PZ, to rapidly inhibit activated factor X (FXa) on...
4.
Izaguirre G, Swanson R, Roth R, Gettins P, Olson S
Biochemistry
. 2021 Apr;
60(15):1201-1213.
PMID: 33822598
Antithrombin is unique among serpin family protein protease inhibitors with respect to the major reactive center loop (RCL) and core conformational changes that mediate allosteric activation of its anticoagulant function...
5.
Huang X, Swanson R, Kroh H, Bock P
J Biol Chem
. 2019 Mar;
294(19):7644-7657.
PMID: 30918026
Current thought holds that factor Xa (FXa) bound in the prothrombinase complex is resistant to regulation by protein protease inhibitors during prothrombin activation. Here we provide evidence that, contrary to...
6.
Chawla A, Williams R, Sich N, Clancy T, Wang J, Ashley S, et al.
J Surg Oncol
. 2018 Sep;
118(6):983-990.
PMID: 30212595
Background And Objectives: Various treatment options exist for patients with metastatic pancreatic neuroendocrine tumors (PNETs). Surgical resection with pancreaticoduodenectomy (PD) typically reserved for patients with limited disease. Definitive data are...
7.
Richard B, Swanson R, Izaguirre G, Olson S
Biochemistry
. 2018 Mar;
57(15):2211-2226.
PMID: 29561141
Heparin allosterically activates the anticoagulant serpin, antithrombin, by binding through a sequence-specific pentasaccharide and inducing activating conformational changes in the protein. Three basic residues of antithrombin, Lys114, Lys125, and Arg129,...
8.
Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, et al.
Cancer Cell
. 2017 Apr;
31(4):576-590.e8.
PMID: 28399412
Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle...
9.
Fairweather M, Swanson R, Wang J, Brais L, Dutton T, Kulke M, et al.
Ann Surg Oncol
. 2017 Mar;
24(8):2319-2325.
PMID: 28303430
Background: Liver-directed therapies have been used to treat neuroendocrine liver metastases (NELM) for both symptomatic improvement and tumor growth control. We reviewed our experience with NELM to investigate the outcomes...
10.
Roth R, Swanson R, Izaguirre G, Bock S, Gettins P, Olson S
J Biol Chem
. 2015 Sep;
290(47):28020-28036.
PMID: 26359493
Past studies have suggested that a key feature of the mechanism of heparin allosteric activation of the anticoagulant serpin, antithrombin, is the release of the reactive center loop P14 residue...