Richard Strasser
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Explore the profile of Richard Strasser including associated specialties, affiliations and a list of published articles.
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Articles
130
Citations
3015
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Recent Articles
1.
Goritzer K, Ruocco V, Vavra U, Izadi S, Bolanos-Martinez O, Phetphoung T, et al.
Front Plant Sci
. 2025 Feb;
15:1531710.
PMID: 39911658
Monoclonal antibodies are crucial recombinant biopharmaceuticals, with -glycosylation at Asn297 essential for their functionality. Plants are increasingly used for antibody production, achieving high expression levels and enabling glycoengineering to produce...
2.
Bolanos-Martinez O, Urbanetz A, Maresch D, Strasser R, Vimolmangkang S
Biotechnol Rep (Amst)
. 2024 Dec;
45:e00865.
PMID: 39691101
The production of cannabinoid compounds such as Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabichromene (CBC) with potential pharmaceutical applications is growing sharply. However, challenges such as the low yield of minor...
3.
Schoberer J, Vavra U, Shin Y, Grunwald-Gruber C, Strasser R
Plant J
. 2024 Dec;
121(1):e17185.
PMID: 39642157
The endoplasmic reticulum (ER) utilizes ER-associated degradation (ERAD), a highly conserved eukaryotic pathway, to eliminate misfolded or unassembled proteins and maintain protein homeostasis in cells. The clearance of misfolded glycoproteins...
4.
Kogelmann B, Melnik S, Keshvari T, Bogner M, Lavoie P, D Aoust M, et al.
N Biotechnol
. 2024 Nov;
85:23-30.
PMID: 39613154
β1,4-galactosylation is a typical human N-glycan formation with functional impact on proteins, particularly known for IgGs. Therefore, the expression of recombinant proteins with controlled galactosylation is an important quality parameter...
5.
Srisangsung T, Phetphoung T, Manopwisedjaroen S, Rattanapisit K, Bulaon C, Thitithanyanont A, et al.
Biotechnol Rep (Amst)
. 2024 Jul;
43:e00847.
PMID: 39040987
Plant-based manufacturing has the advantage of post-translational modifications. While plant-specific N-glycans have been associated with allergic reactions, their effect on the specific immune response upon vaccination is not yet understood....
6.
Goritzer K, Strasser R, Ma J
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 38999969
Secretory IgA (SIgA) presents a promising avenue for mucosal immunotherapy yet faces challenges in expression, purification, and stability. IgA exists in two primary isotypes, IgA1 and IgA2, with IgA2 further...
7.
Krittanai S, Rattanapisit K, Bulaon C, Pitaksajjakul P, Keadsanti S, Ramasoota P, et al.
Biotechnol Rep (Amst)
. 2024 Jun;
42:e00844.
PMID: 38881650
Dengue virus (DENV), transmitted by mosquitoes, is classified into four serotypes (DENV1-4) and typically causes mild, self-limiting symptoms upon initial infection. However, secondary infection can lead to severe symptoms due...
8.
Seeberger P, Ge Y, Szymanski C, Kolarich D, Thaysen-Andersen M, Packer N, et al.
Cell
. 2024 May;
187(11):2628-2632.
PMID: 38788686
Glycans, with their variable compositions and highly dynamic conformations, vastly expand the heterogeneity of whatever factor or cell they are attached to. These properties make them crucial contributors to biological...
9.
Vitayathikornnasak S, Rattanapisit K, Malla A, Suwanchaikasem P, Strasser R, Khorattanakulchai N, et al.
Biotechnol Rep (Amst)
. 2024 May;
42:e00841.
PMID: 38707206
Cobra () venom contains many toxins including α-neurotoxin (αNTX) and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory failure, and even death. The traditional antivenom derived from animal serum faces...
10.
McGinness A, Brooks S, Strasser R, Schoberer J, Kriechbaumer V
J Microsc
. 2024 Apr;
297(3):258-273.
PMID: 38687244
Plant cells are a capable system for producing economically and therapeutically important proteins for a variety of applications, and are considered a safer production system than some existing hosts such...