Richard S Ajioka
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Explore the profile of Richard S Ajioka including associated specialties, affiliations and a list of published articles.
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10
Citations
476
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Recent Articles
1.
Ajioka R, Phillips J, Weiss R, Dunn D, Smit M, Proll S, et al.
Blood
. 2008 Sep;
112(12):4723-8.
PMID: 18809758
Hepatic siderosis is common in patients with porphyria cutanea tarda (PCT). Mutations in the hereditary hemochromatosis (hh) gene (HFE) explain the siderosis in approximately 20% patients, suggesting that the remaining...
2.
De Domenico I, Nemeth E, Nelson J, Phillips J, Ajioka R, Kay M, et al.
Cell Metab
. 2008 Aug;
8(2):146-56.
PMID: 18680715
Mammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin. Hepcidin binds to ferroportin resulting in degradation of ferroportin and...
3.
Ajioka R, LeBoeuf R, Gillespie R, Amon L, Kushner J
Blood Cells Mol Dis
. 2007 May;
39(2):199-205.
PMID: 17493847
The highly variable clinical phenotype observed in patients homozygous for the C282Y mutation of the hereditary hemochromatosis gene (HFE) is likely due to the influence of non-HFE modifier genes. The...
4.
Ajioka R, Phillips J, Kushner J
Biochim Biophys Acta
. 2006 Jul;
1763(7):723-36.
PMID: 16839620
Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin...
5.
Cooksey R, Jouihan H, Ajioka R, Hazel M, Jones D, Kushner J, et al.
Endocrinology
. 2004 Aug;
145(11):5305-12.
PMID: 15308612
The pathogenesis of diabetes associated with hemochromatosis is not known. We therefore examined glucose homeostasis and beta-cell function in mouse models of hemochromatosis. Mice with targeted deletion of the hemochromatosis...
6.
Toomajian C, Ajioka R, Jorde L, Kushner J, Kreitman M
Genetics
. 2003 Sep;
165(1):287-97.
PMID: 14504236
Mutations that have recently increased in frequency by positive natural selection are an important component of naturally occurring variation that affects fitness. To identify such variants, we developed a method...
7.
Ajioka R, Kushner J
Blood
. 2003 Apr;
101(9):3351-3; discussion 3354-8.
PMID: 12707221
No abstract available.
8.
Ajioka R, Kushner J
Semin Hematol
. 2002 Oct;
39(4):235-41.
PMID: 12382198
Hereditary hemochromatosis (hh, type 1 hemochromatosis) is an autosomal recessive trait characterized by hyperabsorption of dietary iron. The disease trait occurs in approximately five per thousand Caucasians of northern European...
9.
Hofmann W, Tong X, Ajioka R, Kushner J, Koeffler H
Blood
. 2002 Aug;
100(3):1099-100.
PMID: 12150153
No abstract available.
10.
Ajioka R, Levy J, Andrews N, Kushner J
Blood
. 2002 Aug;
100(4):1465-9.
PMID: 12149232
Hereditary hemochromatosis is most commonly caused by homozygosity for a point mutation (C282Y) in the human hemochromatosis gene (HFE). The mechanism by which HFE regulates iron absorption is not known,...