Richard M Walmsley
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Explore the profile of Richard M Walmsley including associated specialties, affiliations and a list of published articles.
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28
Citations
208
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Recent Articles
1.
Tate M, Walmsley R
Mutagenesis
. 2017 Oct;
32(5):491-499.
PMID: 28992092
A two-part study was designed to determine whether the inclusion of the rodent liver 'S9' exogenous metabolic activating system contributes to the generation of misleading positive results by the regulator-required...
2.
Rees B, Tate M, Lynch A, Thornton C, Jenkins G, Walmsley R, et al.
Mutagenesis
. 2017 Jan;
32(2):283-297.
PMID: 28057708
Mutagens can be carcinogens, and traditionally, they have been identified in vitro using the Salmonella 'Ames' reverse mutation assay. However, prokaryotic DNA packaging, replication and repair systems are mechanistically very...
3.
Etter S, Birrell L, Cahill P, Scott H, Billinton N, Walmsley R, et al.
Toxicol In Vitro
. 2015 May;
29(7):1425-35.
PMID: 26003925
The genotoxicity of a library of 70 flavour and fragrance substances having a high proportion of in vivo and/or carcinogenicity test data has been assessed using the GADD45a-GLuc 'BlueScreen HC'...
4.
Scott H, Walmsley R
Mutat Res Genet Toxicol Environ Mutagen
. 2015 Mar;
777:68-72.
PMID: 25726177
Boronic acids and their derivatives have been exploited for their pharmacological activity and their utility as intermediates in the synthesis of novel non-boron containing compounds. A recent study reported that...
5.
Johnson D, Hastwell P, Walmsley R
Mutagenesis
. 2013 Mar;
28(4):393-9.
PMID: 23476008
Expression of the human GADD45a gene is increased in TK6 cells exposed to mutagens, clastogens and aneugens. It is known to be regulated through both p53-dependent and p53-independent pathways and...
6.
Bryce S, Avlasevich S, Bemis J, Tate M, Walmsley R, Saad F, et al.
Environ Mol Mutagen
. 2013 Mar;
54(3):180-94.
PMID: 23447390
An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate...
7.
Hughes C, Rabinowitz A, Tate M, Birrell L, Allsup J, Billinton N, et al.
J Biomol Screen
. 2012 Jul;
17(10):1302-15.
PMID: 22786892
Exposure to genotoxic carcinogens leads to increased expression of the GADD45a gene in mammalian cells. This signature of genotoxic hazard has previously been exploited in the GreenScreen HC assay, in...
8.
Topham C, Billinton N, Walmsley R
Toxicol Sci
. 2012 Apr;
128(1):79-91.
PMID: 22491427
The in vitro mammalian genotoxicity tests identify some carcinogens not identified by the bacterial Ames test. However, historically they have produced rather more misleading predictions of carcinogenicity than the Ames...
9.
Walmsley R, Tate M
Methods Mol Biol
. 2011 Dec;
817:231-50.
PMID: 22147576
Mutagens, clastogens, and aneugens cause increased expression of the human GADD45a gene. This has been exploited in the GreenScreen HC genotoxicity assay in which the gene's expression is linked to...
10.
Lynch A, Sasaki J, Elespuru R, Jacobson-Kram D, Thybaud V, De Boeck M, et al.
Environ Mol Mutagen
. 2010 Aug;
52(3):205-23.
PMID: 20740635
The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established...