Richard L Spinieli
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Explore the profile of Richard L Spinieli including associated specialties, affiliations and a list of published articles.
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11
Citations
48
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Recent Articles
1.
Lynch N, De Luca R, Spinieli R, Rillosi E, Thomas R, Sailesh S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763835
Pain therapies that alleviate both pain and sleep disturbances may be the most effective for pain relief, as both chronic pain and sleep loss render the opioidergic system, targeted by...
2.
Spinieli R, Cazuza R, Sales A, Carolino R, Franci J, Tajerian M, et al.
Neurosci Lett
. 2023 Dec;
820:137589.
PMID: 38101612
Depending on its duration and severity, stress may contribute to neuropsychiatric diseases such as depression and anxiety. Studies have shown that stress impacts the hypothalamic-pituitary-adrenal (HPA) axis, but its downstream...
3.
Lynch N, Lima J, Spinieli R, Kaur S
Front Neurosci
. 2023 Apr;
17:1134842.
PMID: 37090798
Opioids provide analgesia, as well as modulate sleep and respiration, all by possibly acting on the μ-opioid receptors (MOR). MOR's are ubiquitously present throughout the brain, posing a challenge for...
4.
Spinieli R, Cornelius-Green J, Cummings K
J Neurophysiol
. 2022 Sep;
128(5):1199-1206.
PMID: 36169206
Previously we showed that a loss of central nervous system (CNS) 5-hydroxytryptamine (5-HT) (tryptophan hydroxylase 2 knockout; TPH2) leads to hypertension in male rats during wakefulness and REM sleep. Here,...
5.
Spinieli R, Cazuza R, Sales A, Carolino R, Martinez D, Anselmo-Franci J, et al.
Mol Pain
. 2022 Aug;
18:17448069221121307.
PMID: 35974687
Chronic pain increases the risk of developing anxiety, with limbic areas being likely neurological substrates. Despite high clinical relevance, little is known about the precise behavioral, hormonal, and brain neuroplastic...
6.
Spinieli R, Ben Musa R, Cornelius-Green J, Hasser E, Cummings K
Am J Physiol Regul Integr Comp Physiol
. 2022 Apr;
322(6):R581-R596.
PMID: 35380477
Orexin neurons are sensitive to CO and contribute to cardiorespiratory homeostasis as well as sensorimotor control. Whether orexin facilitates respiratory and behavioral responses to acute hypoxia is unclear. We hypothesized...
7.
Abuaish S, Lavergne S, Hing B, St-Cyr S, Spinieli R, Boonstra R, et al.
Proc Biol Sci
. 2021 Dec;
288(1964):20211908.
PMID: 34847769
Predation is a key organizing force in ecosystems. The threat of predation may act to programme the endocrine hypothalamic-pituitary-adrenal axis during development to prepare offspring for the environment they are...
8.
Spinieli R, Ben Musa R, Kielhofner J, Cornelius-Green J, Cummings K
Am J Physiol Regul Integr Comp Physiol
. 2021 Aug;
321(4):R558-R571.
PMID: 34405704
Orexin neurons are active in wakefulness and mostly silent in sleep. In adult rats and humans, orexin facilitates the hypercapnic ventilatory response but has little effect on resting ventilation. The...
9.
Amarilla A, Santos-Junior N, Figueiredo M, Luiz J, Fumagalli M, Colon D, et al.
J Infect Dis
. 2019 Feb;
219(12):2015-2025.
PMID: 30715407
Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975-1976 in Sao Paulo State, Brazil. Previous studies have shown an increased...
10.
Abuaish S, Spinieli R, McGowan P
Psychoneuroendocrinology
. 2018 Aug;
98:11-21.
PMID: 30086533
The maternal environment has a profound effect on the development of offspring, including responses to stress mediated by the hypothalamic-pituitary-adrenal (HPA) axis. In rodents, perinatal high fat diet (HFD) has...